A growing number of studies reported that rosiglitazone (a PPARgamma agonist) could
ameliorate the painful state and prevent stress-induced depression. However, whether …

Background The anterior cingulate cortex (ACC) is a brain region that has been critically
implicated in the processing of pain perception and modulation. While much evidence has …

Anxiety disorders are chronic, disabling conditions across the world, and bring a great
burden to individuals and society. Although advances have been made in understanding of …

Background As antidepressants commonly used in the clinic have proved to be problematic,
it is urgent to gain an updated understanding of the pathogenesis of depression and find …

Neuropathic pain is an intractable clinical problem, affecting millions of people worldwide.
Preemptive administration of minocycline has been confirmed useful for treating neuropathic …

Minocycline has been implicated in the treatment for multiple diseases in the nervous
system for its neuroprotective properties. However, the mechanism by which minocycline …

Aims Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes acute and
chronic peripheral neuropathies. We previously reported that repeated administration of …

Descending nociceptive modulation from the supraspinal structures plays an important role
in cancer-induced bone pain (CIBP). Rostral ventromedial medulla (RVM) is a critical …

Global cerebral ischemia (GCI) commonly occurs in the elderly. Subcortical white matter
lesions and oligodendrocyte (OLG) loss caused by cerebral ischemia have been implicated …

Neuropathic pain is a refractory clinical problem. Certain drugs, such as tramadol, proved
useful for the treatment of neuropathic pain by inhibiting the activity of nociceptive neurons …