Depression and anxiety have been reported as the major neuropsychiatric consequences
following stroke. Minocycline, a neuroprotective drug has minimized depressive symptoms …

BACKGROUND: Chemotherapy-induced peripheral neuropathy is a common, dose-limiting
side effect of cancer chemotherapeutic drugs. Hyperalgesia is a common component of …

Cancer-induced bone pain (CIBP) treatment remains a clinical challenge because the
pathophysiological mechanisms are not fully understood. Recently, it was verified that …

It is confirmed that pharmacological attenuation of glial cells can alleviate neuropathic pain
by lowering proinflammatory cytokine expression. The present study tries to confirm that post …

Microglia activation in the spinal cord play a major role in the pathogenesis of neuropathic
pain. The p38 mitogen-activated protein kinase (MAPK) regulates microglia activation …

The current study was to examine the underlying mechanisms responsible for the role of
mammalian target of rapamycin (mTOR) in regulating bone cancer‐evoked pain and the …

Background Bone cancer pain (BCP) severely compromises the quality of life, while current
treatments are still unsatisfactory. Here, we tested the antinociceptive effects of triptolide …

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia. Diabetic
patients are known to have a higher prevalence and a higher risk of depression compared …

In neuropathic pain the repeated minocycline treatment inhibited the mRNA and protein
expression of the microglial markers and metalloproteinase-9 (MMP-9). The minocycline …

Oxaliplatin is a third-generation platinum-based chemotherapeutic drug. Although its
efficacy against colorectal cancer is well known, peripheral neuropathy that develops during …