The pathogenesis of Parkinson's disease (PD) is complex, multilayered, and not fully
understood, resulting in a lack of effective disease-modifying treatments for this prevalent …

Klotho is one of a number of well-known longevity-associated genes. Its depletion in aging
or disease may promote several neuropathologies associated with the central nervous …

Depression is a serious neuropsychiatric disease affecting an increasing number of people
worldwide. Cognitive deficits (including inattention, poor memory, and decision-making …

In this review we outline a rationale for identifying neuroprotectants aimed at inducing
endogenous Klotho activity and expression, which is epigenetic action, by definition. Such …

Abstract α-Klotho is known for its aging-related functions and is associated with
neurodegenerative diseases, accelerated aging, premature morbidity, and mortality. Recent …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder
characterized by the loss of motor neurons in the brain and spinal cord. ALS neuropathology …

Parkinson's disease (PD) is a prevalent movement disorder in the elderly. PD is hallmarked
with progressive deterioration of mesencephalic dopaminergic neurons and development of …

Parkinson's Disease (PD) is a prevalent and complex age-related neurodegenerative
condition for which there are no disease-modifying treatments currently available. The …

The antiaging protein Klotho is encoded by the Klotho gene first identified as an 'aging
suppressor', in mice. Klotho deficiency is involved in premature aging and early death, while …

Klotho, encoded by the KL gene, is a single-pass transmembrane protein and a circulating
factor that plays a key role in cellular metabolism and body homeostasis and has been …