Children are not small adults because besides size there are subtle physiological and
biochemical differences between children and adults. Like adults, children also require …

Background: Physiological‐based pharmacokinetic models have been used to describe
midazolam clearance (CL) maturation. There are no maturation descriptors of CL from …

Physiological maturity is a gradual process taking place throughout infancy and childhood.
Though for years anatomical growth has been the basis for dose calculation in pediatric …

Pediatric physiologically‐based modeling in drug development has grown in the past
decade and optimizing the underlying systems parameters is important in relation to overall …

Background Midazolam is used widely as a sedative to facilitate mechanical ventilation. This
prospective study investigated the population pharmacokinetics of midazolam in very …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• No consensus has been reached so
far on the suitability of different methodologies for dose selection in children.• In paediatric …

Although midazolam is a frequently used sedative in neonatal intensive care units, its use in
preterm neonates has been off‐label. Recently, a new dosing advice for midazolam for …

Background and objective Major changes in cytochrome P450 (CYP) 3A activity may be
expected in the first few months of life with, later, relatively limited changes. In this analysis …

It should be recognized that children are not small adults, hence dosing in children should
not be a 'small adult dose'. A mean population dose in all age groups is just an average …

The objective of this study was to compare the predictive performance of an allometric model
with that of a physiologically based pharmacokinetic (PBPK) model to predict clearance or …