Epidermal growth factor receptor (EGFR) involvement in epithelial‐derived cancers and its current antibody‐based immunotherapies

M London, E Gallo - Cell biology international, 2020 - Wiley Online Library
The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that is part of
the family of tyrosine kinase receptors. The binding of EGFR to its cognate ligands leads to …

Epidermal growth factor receptor inhibition in cancer therapy: biology, rationale and preliminary clinical results

SM Huang, PM Harari - Investigational new drugs, 1999 - Springer
The epidermal growth factor receptor (EGFR), a growth factor receptor involved in the
regulation of cellular differentiation and proliferation, is highly expressed by many tumor …

Critical update and emerging trends in epidermal growth factor receptor targeting in cancer

J Baselga, CL Arteaga - Journal of Clinical Oncology, 2005 - ascopubs.org
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB
receptor family that is abnormally activated in many epithelial tumors. The aberrant …

Anti-epidermal growth factor receptor monoclonal antibodies in cancer therapy

E Martinelli, R De Palma, M Orditura… - Clinical & …, 2009 - academic.oup.com
The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor
involved in the proliferation and survival of cancer cells. EGFR is the first molecular target …

Epidermal growth factor receptor in relation to tumor development: EGFR‐targeted anticancer therapy

I Okamoto - The FEBS journal, 2010 - Wiley Online Library
The discovery that signaling by the epidermal growth factor receptor (EGFR) plays a key role
in tumorigenesis prompted efforts to target this receptor in anticancer therapy. Two different …

Epidermal growth factor receptor: a promising target in solid tumours

JJ Laskin, AB Sandler - Cancer treatment reviews, 2004 - Elsevier
The epidermal growth factor receptor (EGFR) is expressed in a wide variety of solid tumours.
It has been demonstrated that the EGFR-associated signaling pathway plays an important …

Epidermal growth factor receptor targeting in cancer

J Mendelsohn, J Baselga - Seminars in oncology, 2006 - Elsevier
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family
that is abnormally activated in many epithelial tumors. Several mechanisms lead to the …

A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor

F Ciardiello, G Tortora - Clinical Cancer Research, 2001 - AACR
The epidermal growth factor receptor (EGFR) autocrine pathway contributes to a number of
processes important to cancer development and progression, including cell proliferation …

Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia

CL Arteaga - Seminars in oncology, 2002 - Elsevier
The ability of the epidermal growth factor receptor (EGFR) to transform epithelial cells, the
overexpression of EGFR and its ligands in several human carcinomas, and the causal …

Targeted cancer therapies based on antibodies directed against epidermal growth factor receptor: status and perspectives

Z Zhu - Acta Pharmacologica Sinica, 2007 - Wiley Online Library
Compelling experimental and clinical evidence suggests that epidermal growth factor
receptor (EGFR) plays an important role in the pathogenesis of a variety of human cancers; …