The capsaicin (vanilloid) receptor, TRPV1, is a heat-activated cation channel modulated by
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …

Background: The capsaicin receptor TRPV1, a polymodal nociceptor whose expression is
up-regulated in a number of painful inflammatory disorders, represents a promising …

TRPV1 is a noxious heat, capsaicin (vanilloid) and acid receptor for which the development
of antagonists represents a novel therapeutic approach for the treatment of pain. TRPV1 …

As last year marked the tenth anniversary of the cloning of TRPV1, no attenuation has been
observed in the intense interest surrounding this ion channel by both academic labs and …

There is emerging evidence that transient receptor potential (TRP) ion channels expressed
in sensory neurons are important for the transduction of chemical, thermal and mechanical …

The vanilloid receptor TRPV1 is now recognized as a molecular integrator of painful stimuli
ranging from noxious heat to endovanilloids in inflammation. Pharmacological blockade of …

Preclinical research has identified an array of ion channels in sensory neurons involved in
the generation and transduction of pain as potential targets for pharmacological intervention …

Abstract The last decade (2001-2010), declared as the Decade of Pain Control and
Research by the United States Congress, brought significantly advances in our …

Based on the painful effects of exposure to capsaicin, TRPV1 (transient receptor potential
vanilloid subfamily member 1) lo-calization is most readily associated with peripheral …

TRPV1 is a cation channel activated by a range of noxious stimuli and highly expressed in
nociceptive fibres. TRPV1 receptors are involved in pain and sensitisation associated with …