The frequency of chronic renal insufficiency among cancer patients is unclear. The aim of
this study was to determine the frequency of impaired renal function within a population of …

OBJECTIVES.: Carboplatin dosing is usually based on glomerular filtration rate (GFR). The
Cockcroft–Gault and the Modified Diet in Renal Disease (MDRD) Study formulae are based …

Chemotherapeutic agents used to treat cancer generally have narrow therapeutic indices
along with potentially serious adverse toxicities. Many cancer drugs are at least partially …

The narrow therapeutic index of anticancer drugs presents a clinical dilemma when these
agents are administered to patients with impaired or unstable renal function. The purpose of …

Background: Chronic renal failure is a common pathology. The high frequency of this
disease in the general US population has been assessed in the NHANES III study. However …

Background: Glomerular filtration rate (GFR) is used in the calculation of carboplatin dose.
Glomerular filtration rate is measured using a radioisotope method (radionuclide GFR …

Abstract Purpose: The Calvert formula is a widely applied algorithm for the a priori dosing of
carboplatin based on patients glomerular filtration rate (GFR) as accurately measured using …

Chronic kidney disease is a common occurrence in patients with gynecological cancer.
Systemic anticancer treatment in such patients is a challenge for clinicians because of …

Background Nephrotoxicity is the dose-limiting side effect of cisplatin justifying the
assessment of renal function for dose adjustment. Objective To determine whether …

Purpose: Carboplatin is frequently dosed to achieve a desired area under the plasma
concentration-time curve (AUC) by using the Calvert or Chatelut equations to estimate …