[HTML][HTML] Iron and chelation in biochemistry and medicine: new approaches to controlling iron metabolism and treating related diseases

GJ Kontoghiorghes, CN Kontoghiorghe - Cells, 2020 - mdpi.com
Iron is essential for all living organisms. Many iron-containing proteins and metabolic
pathways play a key role in almost all cellular and physiological functions. The diversity of …

Role of iron in the molecular pathogenesis of diseases and therapeutic opportunities

U Abbasi, S Abbina, A Gill, LE Takuechi… - ACS Chemical …, 2021 - ACS Publications
Iron is an essential mineral that serves as a prosthetic group for a variety of proteins involved
in vital cellular processes. The iron economy within humans is highly conserved in that there …

[图书][B] Iron metabolism: from molecular mechanisms to clinical consequences

R Crichton - 2016 - books.google.com
Iron is indispensable for the growth, development and well-being of almost all living
organisms. Biological systems from bacteria, fungi and plants to humans have evolved …

Importance of iron chelation in free radical-induced oxidative stress and human disease

K Jomova, M Valko - Current pharmaceutical design, 2011 - ingentaconnect.com
Iron is a redox active metal involved in the oxidation-reduction reactions and regulation of
cell growth and differentiation. Iron is an integral part of many proteins and enzymes that …

Advances in iron chelation: an update

H Heli, S Mirtorabi, K Karimian - Expert opinion on therapeutic …, 2011 - Taylor & Francis
Introduction: Oxidative stress (caused by excess iron) can result in tissue damage, organ
failure and finally death, unless treated by iron chelators. The causative factor in the etiology …

Iron: mammalian defense systems, mechanisms of disease, and chelation therapy approaches

GJ Kontoghiorghes, ED Weinberg - Blood reviews, 1995 - Elsevier
During the past 6 decades, much attention has been devoted to understanding the uses,
metabolism and hazards of iron in living systems. 1 A great variety of heme and non-heme …

Synthetic and natural iron chelators: therapeutic potential and clinical use

HC Hatcher, RN Singh, FM Torti… - Future medicinal …, 2009 - Taylor & Francis
Iron-chelation therapy has its origins in the treatment of iron-overload syndromes. For many
years, the standard for this purpose has been deferoxamine. Recently, considerable …

[HTML][HTML] Biochemistry, iron absorption

T Ems, K St Lucia, MR Huecker - 2017 - europepmc.org
Iron is an essential element of various metabolic processes in humans, including DNA
synthesis, electron transport, and oxygen transport. Unlike other minerals, iron levels in the …

Potential use of iron chelators against oxidative damage

JB Galey - Advances in pharmacology, 1996 - Elsevier
Publisher Summary Iron is critically involved in dioxygen transport and in a wide variety of
cellular events ranging from respiration to DNA synthesis. The physical properties those …

Iron: effect of overload and deficiency

RC Hider, X Kong - Interrelations between essential metal ions and …, 2013 - Springer
Iron is a redox active metal which is abundant in the Earth's crust. It has played a key role in
the evolution of living systems and as such is an essential element in a wide range of …