Beyond the sleep-amyloid interactions in Alzheimer's disease pathogenesis

S Ning, M Jorfi - Journal of neurophysiology, 2019 - journals.physiology.org
Cognitive impairment in older adults is associated with sleep and circadian rhythm
disturbances. Numerous studies have linked disrupted sleep and circadian rhythms with …

Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors

C Wang, DM Holtzman - Neuropsychopharmacology, 2020 - nature.com
As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

[HTML][HTML] Sleep in Alzheimer's disease–beyond amyloid

JK Holth, TK Patel, DM Holtzman - Neurobiology of sleep and circadian …, 2017 - Elsevier
Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of
institutionalization. Like AD pathology, sleep abnormalities can appear years before …

[HTML][HTML] It's complicated: The relationship between sleep and Alzheimer's disease in humans

BP Lucey - Neurobiology of disease, 2020 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an
asymptomatic period of amyloid-β (Aβ) deposition as insoluble extracellular plaque …

Circadian and sleep dysfunction in Alzheimer's disease

MS Uddin, D Tewari, A Al Mamun, MT Kabir… - Ageing Research …, 2020 - Elsevier
Alzheimer's disease (AD) is a devastating and irreversible cognitive impairment and the
most common type of dementia. Along with progressive cognitive impairment, dysfunction of …

Sleep–wake regulation and the hallmarks of the pathogenesis of Alzheimer's disease

M Van Egroo, J Narbutas, D Chylinski… - Sleep, 2019 - academic.oup.com
While efficient treatments for Alzheimer's disease (AD) remain elusive, a growing body of
research has highlighted sleep–wake regulation as a potential modifiable factor to delay …

The sleep side of aging and Alzheimer's disease

SM Romanella, D Roe, E Tatti, D Cappon, R Paciorek… - Sleep medicine, 2021 - Elsevier
As we age, sleep patterns undergo significant modifications in micro and macrostructure,
worsening cognition and quality of life. These are associated with remarkable brain …

[HTML][HTML] Amyloid-β diurnal pattern: possible role of sleep in Alzheimer's disease pathogenesis

BP Lucey, RJ Bateman - Neurobiology of aging, 2014 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
cognitive decline that is a growing public health crisis with a prevalence projected to more …

[PDF][PDF] Unraveling the Mechanisms Underlying Disordered Sleep in Alzheimer's Disease

R Luke, I Alymova - The Journal of Neuroscience, 2023 - Soc Neuroscience
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the aggregation
of b-amyloid and tau. While cognitive impairment is the primary clinical manifestation of AD …

Sleep as a potential biomarker of tau and β-amyloid burden in the human brain

JR Winer, BA Mander, RF Helfrich… - Journal of …, 2019 - Soc Neuroscience
Recent proposals suggest that sleep may be a factor associated with accumulation of two
core pathological features of Alzheimer's disease (AD): tau and β-amyloid (Aβ). Here we …