The neurobiological mechanisms that regulate the development and maintenance of alcohol
use disorder (AUD) are complex and involve a wide variety of within and between systems …

Background Chronic alcohol exposure produces neuroadaptation, which increases the risk
of cellular excitotoxicity and autonomic dysfunction during withdrawal. The temporal …

The paraventricular nucleus of the thalamus (PVT) is a midline thalamic brain region that
has emerged as a critical circuit node in the regulation of behaviors across domains of affect …

The hypothalamus is now known to regulate alcohol intake in addition to its established role
in food intake, in part through neuromodulatory neurochemicals termed neuropeptides …

Alcohol use disorder (AUD) places a tremendous burden on society, with approximately two
billion alcohol users in the world. While most people drink alcohol recreationally, a …

Peptides synthesized in endocrine cells in the gastrointestinal tract and neurons are
traditionally considered regulators of metabolism, energy intake, and appetite. However …

Highlights•Translational medicine has a major significance in drug development on
alcoholism.•Brain imaging techniques are fundamental in bridging between preclinical and …

Alcoholism is a complex and debilitating syndrome affecting∼ 140 million people
worldwide. However, not everyone who consumes ethanol develops abuse, raising the …

Alcohol dependence is a chronically relapsing disorder characterized by compulsive drug-
seeking and drug-taking, loss of control in limiting intake, and the emergence of a …

Addiction is a chronic disorder that consists of a three-stage cycle of binge/intoxication,
withdrawal/negative affect, and preoccupation/anticipation. These stages involve …