Strategies to expand the therapeutic potential of superoxide dismutase by exploiting delivery approaches

AC Rosa, N Bruni, G Meineri, D Corsi, N Cavi… - International Journal of …, 2021 - Elsevier
The overproduction of free radicals can cause oxidative-stress damage to a range of
biomolecules, and thus potentially contribute to several pathologies, from …

Superoxide dismutase administration: A review of proposed human uses

AC Rosa, D Corsi, N Cavi, N Bruni, F Dosio - Molecules, 2021 - mdpi.com
Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant
defense against oxidative stress in the body. SOD supplementation may therefore trigger the …

On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies

C Muscoli, S Cuzzocrea, DP Riley… - British journal of …, 2003 - Wiley Online Library
The list of pathophysiological conditions associated with the overproduction of superoxide
expands every day. Much of the knowledge compiled on the role of this radical in disease …

[HTML][HTML] Therapeutic potentials of superoxide dismutase

H Younus - International journal of health sciences, 2018 - ncbi.nlm.nih.gov
Superoxide dismutases (SODs) constitute a very important antioxidant defense against
oxidative stress in the body. The enzyme acts as a good therapeutic agent against reactive …

[PDF][PDF] Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono-and polysaccharide derivatives.

T Fujita, M Nishikawa, C Tamaki, Y Takakura… - … of Pharmacology and …, 1992 - Citeseer
Four types of superoxide dismutase(SOD) derivatives such as SOD-carboxymethyl dextran
conjugate, SOD-diethylaminoethyl dextran conjugate, galactosylated SOD and …

Oxidative stress in neurodegenerative diseases: therapeutic implications for superoxide dismutase mimetics

K Pong - Expert opinion on biological therapy, 2003 - Taylor & Francis
Evidence of oxidative stress is apparent in both acute and chronic neurodegenerative
diseases, such as stroke, Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) …

Recombinant human superoxide dismutases: production and potential therapeutical uses

M Gorecki, Y Beck, JR Hartman, M Fischer… - Free radical research …, 1991 - Taylor & Francis
In many pathological situations, tissue damage is caused by cellular generation of
superoxide free radicals (O2-). These active species are generated during post-ischemic …

Superoxide dismutase administration, a potential therapy against oxidative stress related diseases: several routes of supplementation and proposal of an original …

J Carillon, JM Rouanet, JP Cristol, R Brion - Pharmaceutical research, 2013 - Springer
Oxidative stress, involved in many diseases, is defined as an impaired balance between
reactive oxygen species (ROS) production and antioxidant defences. Antioxidant enzymes …

Superoxide dismutase and catalase as therapeutic agents for human diseases a critical review

RA Greenwald - Free Radical Biology and Medicine, 1990 - Elsevier
The list of human and animal diseases for which oxygen radical scavenging therapy is being
recommended continues to grow, based primarily on inferential evidence suggesting a …

A drug formulation using an alginate hydrogel matrix for efficient oral delivery of the manganese porphyrin-based superoxide dismutase mimic

T Aikawa, S Ito, M Shinohara, M Kaneko, T Kondo… - Biomaterials …, 2015 - pubs.rsc.org
In order for patients to avail of the therapeutic benefits of antioxidant drugs efficiently and
conveniently, a robust oral delivery system needs to be developed. However, a common …