Rhea, the reaction knowledgebase in 2022

P Bansal, A Morgat, KB Axelsen… - Nucleic acids …, 2022 - academic.oup.com
Abstract Rhea (https://www. rhea-db. org) is an expert-curated knowledgebase of
biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of …

Updates in Rhea—an expert curated resource of biochemical reactions

A Morgat, T Lombardot, KB Axelsen, L Aimo… - Nucleic acids …, 2016 - academic.oup.com
Abstract Rhea (http://www. rhea-db. org) is a comprehensive and non-redundant resource of
expert-curated biochemical reactions designed for the functional annotation of enzymes and …

Enzyme annotation in UniProtKB using Rhea

A Morgat, T Lombardot, E Coudert, K Axelsen… - …, 2020 - academic.oup.com
Motivation To provide high quality computationally tractable enzyme annotation in
UniProtKB using Rhea, a comprehensive expert-curated knowledgebase of biochemical …

Updates in Rhea: SPARQLing biochemical reaction data

T Lombardot, A Morgat, KB Axelsen, L Aimo… - Nucleic acids …, 2019 - academic.oup.com
Abstract Rhea (http://www. rhea-db. org) is a comprehensive and non-redundant resource of
over 11 000 expert-curated biochemical reactions that uses chemical entities from the ChEBI …

Rhea—a manually curated resource of biochemical reactions

R Alcántara, KB Axelsen, A Morgat, E Belda… - Nucleic acids …, 2012 - academic.oup.com
Abstract Rhea (http://www. ebi. ac. uk/rhea) is a comprehensive resource of expert-curated
biochemical reactions. Rhea provides a non-redundant set of chemical transformations for …

MACiE: exploring the diversity of biochemical reactions

GL Holliday, C Andreini, JD Fischer… - Nucleic acids …, 2012 - academic.oup.com
MACiE (which stands for Mechanism, Annotation and Classification in Enzymes) is a
database of enzyme reaction mechanisms, and can be accessed from http://www. ebi. ac …

ChEBI in 2016: Improved services and an expanding collection of metabolites

J Hastings, G Owen, A Dekker, M Ennis… - Nucleic acids …, 2016 - academic.oup.com
ChEBI is a database and ontology containing information about chemical entities of
biological interest. It currently includes over 46 000 entries, each of which is classified within …

The ChEBI reference database and ontology for biologically relevant chemistry: enhancements for 2013

J Hastings, P De Matos, A Dekker, M Ennis… - Nucleic acids …, 2012 - academic.oup.com
Abstract ChEBI (http://www. ebi. ac. uk/chebi) is a database and ontology of chemical entities
of biological interest. Over the past few years, ChEBI has continued to grow steadily in …

UniPathway: a resource for the exploration and annotation of metabolic pathways

A Morgat, E Coissac, E Coudert… - Nucleic acids …, 2012 - academic.oup.com
Abstract UniPathway (http://www. unipathway. org) is a fully manually curated resource for
the representation and annotation of metabolic pathways. UniPathway provides explicit …

Enzyme annotation for orphan and novel reactions using knowledge of substrate reactive sites

N Hadadi, H MohammadiPeyhani… - Proceedings of the …, 2019 - National Acad Sciences
Thousands of biochemical reactions with characterized activities are “orphan,” meaning they
cannot be assigned to a specific enzyme, leaving gaps in metabolic pathways. Novel …