In the normal diploid mouse embryo, active demethylation of the paternal genome but not of
the maternal genome occurs within only a few hours and in a highly coordinated fashion as …

DNA methylation is essential for the control of a number of biological mechanisms in
mammals [1]. Mammalian development is accompanied by two major waves of genome …

This paper shows stage-and tissue-specific global demethylation and remethylation
occurring during embryonic development. The egg genome is strikingly undermethylated …

In mouse and most other mammalian species, the paternal and maternal genomes undergo
parent-specific epigenetic reprogramming during preimplantation development. The …

The fertilized mouse egg actively demethylates the paternal genome within a few hours after
fertilization, whereas the maternal genome is only passively demethylated by a replication …

Global demethylation of DNA which marks the onset of development occurs asynchronously
in the mouse; paternal DNA is demethylated at the zygote stage, whereas maternal DNA is …

Dynamic epigenetic modification of the genome occurs during early development of the
mouse. Active demethylation of the paternal genome occurs in the zygote, followed by …

Active demethylation of the paternal genome but not of the maternal genome occurs in
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …

The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-
methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish …

We report on observations of the global methylation/demethylation pattern of both pronuclei
in human zygotes and in early embryos up to the blastocyst stage. Our results demonstrate …