Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …

Human immunodeficiency virus (HIV) is still a serious global health concern responsible for
more than 25 million deaths in last three decades. More than 34 million people are living …

HIV-1 has evolved mechanisms to evade host cell immune responses and persist for lifelong
infection. Latent cellular reservoirs are responsible for this persistence of HIV-1 despite the …

Human immunodeficiency virus type 1 (HIV-1) targets CD4+ T cells and cells of the
monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T …

Although CD4+ T cells represent the major reservoir of persistent HIV and SIV infection,
accumulating evidence suggests that macrophages also contribute. However, investigations …

Cells of the macrophage lineage play an important role in initial infection with HIV-1 and
contribute to the pathogenesis of the disease throughout the course of infection. Both blood …

Monocytes and macrophages are targets of HIV-1 infection and play critical roles in multiple
aspects of viral pathogenesis. HIV-1 can replicate in blood monocytes, although only a …

The introduction of the highly active antiretroviral therapy (HAART) has greatly improved
survival. However, these treatments fail to definitively cure the patients and unveil the …

Macrophages are pivotal for the regulation of immune and inflammatory responses, but
whether their role in HIV infection is protective or deleterious remains unclear. In this study …

Macrophages play a crucial role in innate and adaptative immunity in response to
microorganisms and are an important cellular target during HIV-1 infection. Recently, the …