Despite the great breakthroughs in the past few decades in illuminating the pathological
mechanisms of cancer and in developing new anticancer drugs, it remains extremely …

The establishment and application of biomimetic preclinical tumor models for generalizable
and high-throughput antitumor screening play a promising role in drug discovery and cancer …

Significant strides have been made in the development of in vitro systems for disease
modelling. However, the requirement of microenvironment control has placed limitations on …

Current in vitro antitumor drug screening strategies insufficiently mimic biological systems.
They tend to lack true perfusion and draining microcirculation systems, which may post …

The tumor microenvironment plays a critical role in tumor growth, progression, and
therapeutic resistance, but interrogating the role of specific tumor-stromal interactions on …

Future biosensing applications will require high performance, including real-time monitoring
of physiological events, incorporation of biosensors into feedback-based devices, detection …

In vitro engineering of tumor milieus is complex because cancer progression and metastasis
involve spatio-temporally evolving cell–matrix interactions, myriad interactions between …

Animal models have been extensively used in cancer pathology studies and drug discovery.
These models, however, fail to reflect the complex human tumor microenvironment and do …

In vitro cancer 3D models are valuable tools to provide mechanistic insight into solid tumor
growth, invasion, and drug delivery. The 3D spheroid model of solid tumors has been the …

The tumor microenvironment (TME) influences cancer progression. Therefore, engineered
TME models are being developed for fundamental research and anti-cancer drug screening …