Objectives: The objective of this study was to use novel statistical methods to determine the
correlation between HIV-1-specific cytolytic T-lymphocyte (CTL) activity and HIV-1 plasma …

This study addressed the role of T-cell immune activation in determining HIV-1 plasma viral
load and CD4+ T-cell blood levels during HIV-1 infection. A decrease of blood CD4 levels …

Most immunopathogenesis studies of HIV-1 use peripheral blood. Most lymphocytes reside
in lymphoid tissues, however, and the extent to which blood mirrors tissues is unclear. Here …

We determined the representation in asymptomatic human immunodeficiency virus (HIV)
infection of the CD45RO+ and CD45RO− CD45RA+ subsets of CD4+ and CD8+ T …

Whereas T-cell activation parameters of HIV disease have been extensively studied, the
activation status of circulating monocytes has received less attention. Sixty-one subjects with …

A cohort of 98 HIV-infected initially AIDS-free homosexual men from the Multicenter AIDS
Cohort Study (MACS) was followed for 6 years to investigate whether CD8+ cell subsets …

Human immunodeficiency virus type 1 (HIV-1)-infected individuals, but not HIV-seronegative
controls, have non-HLA-restricted T-cell receptor [alpha][beta]+ CD8+ cytotoxic T …

Cytolytic T lymphocytes (CTL) play an important role in the control of HIV infection. The
eventual failure to contain HIV-1 infection may arise because of a functional impairment of …

Background: CD8+ T-cell counts usually increase soon after infection with HIV, whereas
CD4+ cell counts decrease. The result of these changes in T-cell subpopulation subsets in …

In this study, we asked whether there is a difference in the number of CD4+ and CD4−
peripheral blood monocytes as CD4+ T cells decrease during HIV-mediated …