[HTML][HTML] From cell spheroids to vascularized cancer organoids: Microfluidic tumor-on-a-chip models for preclinical drug evaluations
Chemotherapy is one of the most effective cancer treatments. Starting from the discovery of
new molecular entities, it usually takes about 10 years and 2 billion US dollars to bring an …
new molecular entities, it usually takes about 10 years and 2 billion US dollars to bring an …
Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance
Recent developments of organoids engineering and organ-on-a-chip microfluidic
technologies have enabled the recapitulation of the major functions and architectures of …
technologies have enabled the recapitulation of the major functions and architectures of …
Use and application of organ-on-a-chip platforms in cancer research
Y Yu, TT Zhou, L Cao - Journal of Cell Communication and Signaling, 2023 - Springer
Tumors are a major cause of death worldwide, and much effort has been made to develop
appropriate anti-tumor therapies. Existing in vitro and in vivo tumor models cannot reflect the …
appropriate anti-tumor therapies. Existing in vitro and in vivo tumor models cannot reflect the …
A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine
E Steinberg, R Friedman, Y Goldstein… - Communications …, 2023 - nature.com
Optimal clinical outcomes in cancer treatments could be achieved through the development
of reliable, precise ex vivo tumor models that function as drug screening platforms for patient …
of reliable, precise ex vivo tumor models that function as drug screening platforms for patient …
Advances in 3D vascularized tumor-on-a-Chip technology
Tumors disrupt the normal homeostasis of human body as they proliferate in abnormal
speed. For constant proliferation, tumors recruit new blood vessels transporting nutrients …
speed. For constant proliferation, tumors recruit new blood vessels transporting nutrients …
The tumor-on-chip: Recent advances in the development of microfluidic systems to recapitulate the physiology of solid tumors
G Trujillo-de Santiago, BG Flores-Garza… - Materials, 2019 - mdpi.com
The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …
understanding of cancer etiology and development of better anticancer therapies—is highly …
Organ-tumor-on-a-chip for chemosensitivity assay: a critical review
With a mortality rate over 580,000 per year, cancer is still one of the leading causes of death
worldwide. However, the emerging field of microfluidics can potentially shed light on this …
worldwide. However, the emerging field of microfluidics can potentially shed light on this …
Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids
VS Shirure, Y Bi, MB Curtis, A Lezia… - Lab on a Chip, 2018 - pubs.rsc.org
Most cancer treatment strategies target cell proliferation, angiogenesis, migration, and
intravasation of tumor cells in an attempt to limit tumor growth and metastasis. An in vitro …
intravasation of tumor cells in an attempt to limit tumor growth and metastasis. An in vitro …
On-chip anticancer drug screening–Recent progress in microfluidic platforms to address challenges in chemotherapy
There is an increasing need for advanced and inexpensive preclinical models to accelerate
the development of anticancer drugs. While costly animal models fail to predict human …
the development of anticancer drugs. While costly animal models fail to predict human …
Technological advances in tumor-on-chip technology: From bench to bedside
Simple Summary Various 3D in vitro tumor models are rapidly advancing cancer research.
Unlike animal models, they can be produced quickly and are amenable to high-throughput …
Unlike animal models, they can be produced quickly and are amenable to high-throughput …