Combining genetically-encoded biosensors with high throughput strain screening to maximize erythritol production in Yarrowia lipolytica

X Qiu, P Xu, X Zhao, G Du, J Zhang, J Li - Metabolic engineering, 2020 - Elsevier
Erythritol is an important sweetener ingredient and chemical precursor for synthesizing
materials with phase transition behavior. Commercial erythritol is primarily produced by …

Metabolic engineering of Yarrowia lipolytica for thermoresistance and enhanced erythritol productivity

N Wang, P Chi, Y Zou, Y Xu, S Xu, M Bilal… - Biotechnology for …, 2020 - Springer
Background Functional sugar alcohols have been widely used in the food, medicine, and
pharmaceutical industries for their unique properties. Among these, erythritol is a zero …

Characterization of erythrose reductase from Yarrowia lipolytica and its influence on erythritol synthesis

T Janek, A Dobrowolski, A Biegalska… - Microbial Cell …, 2017 - Springer
Background Erythritol is a natural sweetener that is used in the food industry. It is produced
as an osmoprotectant by bacteria and yeast. Due to its chemical properties, it does not …

Engineering the architecture of erythritol-inducible promoters for regulated and enhanced gene expression in Yarrowia lipolytica

YK Park, P Korpys, M Kubiak, E Celińska… - FEMS yeast …, 2019 - academic.oup.com
The non-conventional model yeast Yarrowia lipolytica is of increasing interest as a cell
factory for producing recombinant proteins or biomolecules with biotechnological or …

Engineering oxidative stress defense pathways to build a robust lipid production platform in Yarrowia lipolytica

P Xu, K Qiao, G Stephanopoulos - Biotechnology and …, 2017 - Wiley Online Library
Microbially derived lipids have recently attracted renewed interests due to their broad
applications in production of green diesels, cosmetic additives, and oleochemicals …

Enhancing erythritol production from crude glycerol in a wild-type Yarrowia lipolytica by metabolic engineering

S Yang, X Pan, Q Wang, Q Lv, X Zhang… - Frontiers in …, 2022 - frontiersin.org
Background: Erythritol is a zero-calorie sweetener that is widely used in the food,
pharmaceutical, and medical industries. Crude glycerol is the main by-product of biodiesel …

Identification and characterization of EYK1, a key gene for erythritol catabolism in Yarrowia lipolytica

F Carly, H Gamboa-Melendez, M Vandermies… - Applied microbiology …, 2017 - Springer
Erythritol is a four-carbon sugar alcohol synthesized by osmophilic yeasts, such as Yarrowia
lipolytica, in response to osmotic stress. This metabolite has application as food additive due …

Systematic metabolic engineering of Yarrowia lipolytica for the enhanced production of erythritol

S Yang, X Pan, J You, B Guo, Z Liu, Y Cao, G Li… - Bioresource …, 2024 - Elsevier
In recent times, there has been a growing interest in exploring microbial strains that exhibit
enhanced erythritol productivity. Nonetheless, the lack of advanced synthetic biology tools …

Concomitant Production of Erythritol and β-Carotene by Engineered Yarrowia lipolytica

S Xu, X Zhang, Y Zhang, Q Li, L Ji… - Journal of Agricultural …, 2023 - ACS Publications
While the expansion of the erythritol production industry has resulted in unprecedented
production of yeast cells, it also suffers from a lack of effective utilization. β-Carotene is a …

Alternative Substrate Metabolism in Yarrowia lipolytica

M Spagnuolo, M Shabbir Hussain, L Gambill… - Frontiers in …, 2018 - frontiersin.org
Recent advances in genetic engineering capabilities have enabled the development of
oleochemical producing strains of Yarrowia lipolytica. Much of the metabolic engineering …