Low back pain is a leading cause of disability worldwide and studies have demonstrated
intervertebral disc (IVD) degeneration as a major risk factor. While many in vitro models …

The purpose of this review was to evaluate data generated by animal models of
intervertebral disc (IVD) degeneration published in the last decade and show how this has …

Lower back pain is the leading cause of disability worldwide. Discogenic pain secondary to
intervertebral disc degeneration is a significant cause of low back pain. Disc degeneration is …

Intervertebral disc degeneration is considered a major cause of back pain that places a
heavy burden on society, both because of its effect on the physiology of individuals and its …

Since low-back pain is increasing in ageing populations, current research efforts are
focused on obtaining a better understanding of the pathophysiology of intervertebral disc …

Intervertebral disc (IVD) degeneration is an often investigated pathophysiological condition
because of its implication in causing low back pain. As human material for such studies is …

Intervertebral disc degeneration (IVDD), a widely recognized cause of lower back pain, is
the leading cause of disability worldwide. A myriad of preclinical in vivo animal models of …

Low back pain is associated with degeneration of the intervertebral disc, but specific
mechanisms of pain generation in this pathology remain unknown. Sensory afferent nerve …

One of the frequent causes of low back pain is intervertebral disc degeneration (IDD), which
is followed by discogenic pain. Some significant risk factors that have been linked to the …

Orthopedic research into chronic discogenic back pain has commonly focused on aging‐
and degeneration‐related changes in intervertebral disc structure, biomechanics, and …