Extracellular adenosine triphosphate (eATP) and its main metabolite adenosine (ADO)
constitute an intrinsic part of immunological network in tumor immunity. The concentrations …

Cancer is still one of the world's most pressing health-care challenges, leading to a high
number of deaths worldwide. Immunotherapy is a new developing therapy that boosts …

Cancer immunotherapy based on immune-checkpoint inhibition or adoptive cell therapy has
revolutionized cancer care. Nevertheless, a large proportion of patients do not benefit from …

Adenosine is an evolutionary ancient metabolic regulator linking energy state to physiologic
processes, including immunomodulation and cell proliferation. Tumors create an adenosine …

Adenosine, an immunosuppressive metabolite, is produced by adenosine triphosphate
(ATP) released from dying or stressed cells and is found at high levels in the tumor …

As a new pillar of cancer therapy, tumor immunotherapy has brought irreplaceable durable
responses in tumors. Considering its low response rate, additional immune regulatory …

It is now well known that tumor immunosurveillance contributes to the control of cancer
growth. Many mechanisms can be used by cancer cells to avoid the antitumor immune …

Cancer is a chronic disease and its pathogenesis is well correlated with infection and
inflammation. Adenosine is a purine nucleoside, which is produced under metabolic stress …

T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

Tumor cells overcome anti‐tumor responses in part through immunosuppressive
mechanisms. There are several immune modulatory mechanisms. Among them, adenosine …