Loss of follicles together with decreased oocyte quality and quantity contribute to age-
associated ovarian senescence and infertility. Although underlying mechanisms for ovarian …

Recent advances highlight the pivotal role of nicotinamide adenine dinucleotide (NAD+) in
ovarian aging. However, the roles of de novo NAD+ biosynthesis on ovarian aging are still …

In recent years, postponement of marriage and childbearing in women of reproductive age
has led to an increase in the incidence of age-related infertility. The reproductive aging …

Abstract Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox
reactions, is closely associated with age-related functional degeneration and metabolic …

Advanced maternal age is highly associated with a decline in oocyte quality, but effective
approaches to improve it have still not been fully determined. Here, we report that in vivo …

Object To explore the mechanisms of ovarian aging, we performed overall analysis on the
age-related alterations of gene expression profiles in mouse germinal vesicle (GV) stage …

The number of mitochondria in the oocyte along with their functions (eg, energy production,
scavenger activity) decline with age progression. Such multifaceted functions support …

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

STUDY QUESTION Are human ovarian aging and the age-related female fertility decline
caused by oxidative stress and mitochondrial dysfunction in oocytes? SUMMARY ANSWER …

Ovarian aging affects the reproductive health of elderly women due to decline in oocyte
quality, which is closely related to mitochondrial dysfunction. Nicotinamide mononucleotide …