The neural mechanism of parkinsonian motor symptoms, ie, rigidity, tremor and akinesia,
which are the result of nigrostriatal dopamine deficiency, is interpreted from long-term …

The nonmotor features of Parkinson's disease: pathophysiolog... : Current Opinion in
Neurology The nonmotor features of Parkinson's disease: pathophysiology and …

The motor signs of Parkinson's disease are thought to result in large part from a reduction of
the level of dopamine in the basal ganglia. Over the last few years, many of the functional …

The etiology and pathogenesis of Parkinson's disease have remained a mystery since the
first description of the disease, but the neuropathology of the disorder, as we now know it, is …

The pathophysiology of akinesia and chorea involve disruption of the motor basal ganglia
circuit. This circuit begins with cortical output to the striatum, followed by projections from …

Parkinson's disease (PD) is histologically characterized by the accumulation of α-synuclein
particles, known as Lewy bodies. The second most common neurodegenerative disorder …

Clinical and neuropathologic data in 45 patients with Parkinson's disease (PD) were
compared. Twenty-seven patients suffered from marked akinesia and rigidity (AR-type) and …

Parkinsonism is a clinical syndrome characterized by akinesia, muscular rigidity, and resting
tremor. The most frequent cause of parkinsonism is Parkinson's disease (PD). Progressive …

Mental dysfunction including dementia in Parkinson's disease (PD), the incidence of which
averages 20–40%, is suggested to have six-fold lifetime risk compared to age-matched …

Clinicopathological studies have shown that the accuracy of a clinical diagnosis of
Parkinson''s disease (PD) is less than 80%. More selected diagnostic criteria can increase …