The host genomic environment of the provirus determines the abundance of HTLV-1–infected T-cell clones
Human T-lymphotropic virus type 1 (HTLV-1) persists by driving clonal proliferation of
infected T lymphocytes. A high proviral load predisposes to HTLV-1–associated diseases …
infected T lymphocytes. A high proviral load predisposes to HTLV-1–associated diseases …
HTLV-1–infected T cells contain a single integrated provirus in natural infection
Human T lymphotropic virus type 1 (HTLV-1) appears to persist in the chronic phase of
infection by driving oligoclonal proliferation of infected T cells. Our recent high-throughput …
infection by driving oligoclonal proliferation of infected T cells. Our recent high-throughput …
[HTML][HTML] HTLV-1 clonality in adult T-cell leukaemia and non-malignant HTLV-1 infection
CRM Bangham, LB Cook, A Melamed - Seminars in cancer biology, 2014 - Elsevier
Human T lymphotropic virus type 1 (HTLV-1) causes a range of chronic inflammatory
diseases and an aggressive malignancy of T lymphocytes known as adult T-cell …
diseases and an aggressive malignancy of T lymphocytes known as adult T-cell …
HTLV-1-associated diseases.
T Watanabe - International journal of hematology, 1997 - europepmc.org
HTLV-1-infection is associated with a variety of human diseases including adult T-cell
leukemia (ATL) and non-neoplastic inflammatory diseases. The latter includes HTLV-1 …
leukemia (ATL) and non-neoplastic inflammatory diseases. The latter includes HTLV-1 …
[HTML][HTML] The nature of the HTLV-1 provirus in naturally infected individuals analyzed by the viral DNA-capture-seq approach
The retrovirus human T-cell leukemia virus type 1 (HTLV-1) integrates into the host DNA,
achieves persistent infection, and induces human diseases. Here, we demonstrate that viral …
achieves persistent infection, and induces human diseases. Here, we demonstrate that viral …
[HTML][HTML] HTLV-1 integration into transcriptionally active genomic regions is associated with proviral expression and with HAM/TSP
Human T-lymphotropic virus type 1 (HTLV-1) causes leukaemia or chronic inflammatory
disease in∼ 5% of infected hosts. The level of proviral expression of HTLV-1 differs …
disease in∼ 5% of infected hosts. The level of proviral expression of HTLV-1 differs …
[HTML][HTML] Genome-wide determinants of proviral targeting, clonal abundance and expression in natural HTLV-1 infection
The regulation of proviral latency is a central problem in retrovirology. We postulate that the
genomic integration site of human T lymphotropic virus type 1 (HTLV-1) determines the …
genomic integration site of human T lymphotropic virus type 1 (HTLV-1) determines the …
Mechanisms of human T-lymphotropic virus type 1 transmission and disease
MD Lairmore, R Haines, R Anupam - Current opinion in virology, 2012 - Elsevier
Human T-lymphotrophic virus type-1 (HTLV-1) infects approximately 15–20 million people
worldwide, with endemic areas in Japan, the Caribbean, and Africa. The virus is spread …
worldwide, with endemic areas in Japan, the Caribbean, and Africa. The virus is spread …
How does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)?
CRM Bangham, L Ratner - Current opinion in virology, 2015 - Elsevier
Highlights•Molecular mechanisms of HTLV-1 oncogenesis.•Innate and acquired immune
response to HTLV-1.•Clonality of HTLV-1 in vivo.•We bring together the host and viral factors …
response to HTLV-1.•Clonality of HTLV-1 in vivo.•We bring together the host and viral factors …
Proliferation of HTLV-1 infected circulating cells in vivo in all asymptomatic carriers and patients with TSP/HAM.
M Cavrois, A Gessain, S Wain-Hobson, E Wattel - Oncogene, 1996 - europepmc.org
Assuming that the clonal expansion of T cells harbouring the human T-cell leukemia virus
type 1 (HTLV-1) provirus is a central feature of HTLV-1 infection, the identification of such …
type 1 (HTLV-1) provirus is a central feature of HTLV-1 infection, the identification of such …