Stem cell therapy has shown great efficacy in many diseases. However, the treatment
mechanism is still unclear, which is a big obstacle for promoting clinical research. Therefore …

The selective permeability of the plasma membrane prohibits most exogenous agents from
gaining cellular access. Since many therapeutics and reporter molecules must be …

In this brief introduction to the third edition of the series, I reprint the preface to the previous
edition on cell-penetrating peptides (CPPs) in Methods of Molecular Biology [1](see below) …

Cell-penetrating peptides (CPPs) are short peptides (fewer than 30 amino acids) that have
been predominantly used in basic and preclinical research during the last 30 years. Since …

Different approaches have been developed for the introduction of macromolecules, proteins
and DNA into target cells. Viral (retroviruses, lentiviruses, etc.) and nonviral (liposomes …

Biophysical studies have a very high impact on the understanding of internalization,
molecular mechanisms, interactions, and localization of CPPs and CPP/cargo conjugates in …

In the last 15 years, an ever expanding pool of cell-penetrating peptides (CPPs) has been
discovered and recently focus has shifted towards improving already existing CPPs by …

Anticancer drug delivery has been hindered due to cell membrane permeability and the lack
of a selective marker for tumor cells. Cell permeability is related to the bioavailability of drugs …

Many biologically active compounds, including macromolecules that are used as various
kinds of drugs, must be delivered to the interior of cell or organelles such as mitochondria or …

Delivery of imaging reagents and drugs to tumors is essential for cancer diagnosis and
therapy. In addition to therapeutic and diagnostic functionalities, peptides have potential …