The role of the microbiome in nonhealing diabetic wounds
LR Kalan, MB Brennan - Annals of the New York Academy of …, 2019 - Wiley Online Library
Wound healing is a highly coordinated and complex process, and there can be devastating
consequences if it is interrupted. It is believed that, in combination with host factors …
consequences if it is interrupted. It is believed that, in combination with host factors …
[PDF][PDF] Strain-and species-level variation in the microbiome of diabetic wounds is associated with clinical outcomes and therapeutic efficacy
Chronic wounds are a major complication of diabetes associated with high morbidity and
health care expenditures. To investigate the role of colonizing microbiota in diabetic wound …
health care expenditures. To investigate the role of colonizing microbiota in diabetic wound …
[HTML][HTML] High levels of oxidative stress create a microenvironment that significantly decreases the diversity of the microbiota in diabetic chronic wounds and promotes …
JH Kim, PR Ruegger, EG Lebig… - Frontiers in Cellular …, 2020 - frontiersin.org
Diabetics chronic wounds are characterized by high levels of oxidative stress (OS) and are
often colonized by biofilm-forming bacteria that severely compromise healing and can result …
often colonized by biofilm-forming bacteria that severely compromise healing and can result …
Redefining the chronic-wound microbiome: fungal communities are prevalent, dynamic, and associated with delayed healing
L Kalan, M Loesche, BP Hodkinson, K Heilmann… - MBio, 2016 - Am Soc Microbiol
Chronic nonhealing wounds have been heralded as a silent epidemic, causing significant
morbidity and mortality especially in elderly, diabetic, and obese populations. Polymicrobial …
morbidity and mortality especially in elderly, diabetic, and obese populations. Polymicrobial …
The wound microbiome
EK White, EA Grice - Cold Spring Harbor Perspectives in …, 2023 - cshperspectives.cshlp.org
Breach of the skin barrier and subsequent wound healing occur in the context of microbial
communities of bacteria, fungi, and viruses. These polymicrobial communities are dynamic …
communities of bacteria, fungi, and viruses. These polymicrobial communities are dynamic …
New molecular techniques to study the skin microbiota of diabetic foot ulcers
JP Lavigne, A Sotto, C Dunyach-Remy… - Advances in wound …, 2015 - liebertpub.com
Significance: Diabetic foot ulcers (DFU) are a major and growing public health problem.
They pose difficulties in clinical practice in both diagnosis and management. Bacterial …
They pose difficulties in clinical practice in both diagnosis and management. Bacterial …
The wound microbiome: modern approaches to examining the role of microorganisms in impaired chronic wound healing
Significance: Bacterial burden is believed to play a significant role in impaired wound
healing of chronic wounds and the development of infection-related complications. The …
healing of chronic wounds and the development of infection-related complications. The …
[HTML][HTML] Microbiota of chronic diabetic wounds: ecology, impact, and potential for innovative treatment strategies
World Health Organization considered diabetes as one of the 20th century epidemics,
estimating that over 10% of the world population is diabetic or at high risk. Self-assessment …
estimating that over 10% of the world population is diabetic or at high risk. Self-assessment …
[HTML][HTML] The dynamic wound microbiome
Abstract Background Diabetic foot ulcers (DFUs) account for the majority of all limb
amputations and hospitalizations due to diabetes complications. With 30 million cases of …
amputations and hospitalizations due to diabetes complications. With 30 million cases of …