The diabetic foot: the importance of biofilms and wound bed preparation

SC Davis, L Martinez, R Kirsner - Current diabetes reports, 2006 - Springer
Biofilms are ubiquitous and medically important complex structures consisting of microbial-
associated cells embedded in self-produced extracellular matrix of hydrated extrapolymeric …

Microenvironment and microbiology of skin wounds: the role of bacterial biofilms and related factors

A Scalise, A Bianchi, C Tartaglione, E Bolletta… - Seminars in vascular …, 2015 - Elsevier
Wound healing is a systemic response to injury that impacts the entire body and not just the
site of tissue damage; it represents one of the most complex biological processes. Our …

Macroscale spatial variation in chronic wound microbiota: a cross‐sectional study

LB Price, CM Liu, YM Frankel… - Wound Repair and …, 2011 - Wiley Online Library
Controlling for sample site is considered to be an important aspect of chronic wound
microbiological investigations; yet, macroscale spatial variation in wound microbiota has not …

Survey of fungi and yeast in polymicrobial infections in chronic wounds

SE Dowd, J Delton Hanson, E Rees… - Journal of wound …, 2011 - magonlinelibrary.com
Objective: To assess the incidence, abundance and species diversity of fungi in chronic
wounds, as well as to describe the associations of major fungi populations. Method …

[PDF][PDF] Understanding the effects of bacterial communities and biofilms on wound healing

S Percival, P Bowler - World Wide Wounds, 2004 - institutobeatrizyamada.com.br
For survival and reproductive success, species of bacteria often rely on close relationships
with other species. A collection of bacteria occupying the same physical habitat is called …

Colonizing microbiota is associated with clinical outcomes in diabetic wound healing

G Wang, Z Lin, Y Li, L Chen, SK Reddy, Z Hu… - Advanced drug delivery …, 2023 - Elsevier
With the development of society and the improvement of life quality, more than 500 million
people are affected by diabetes. More than 10% of people with diabetes will suffer from …

Microscopy visualisation confirms multi‐species biofilms are ubiquitous in diabetic foot ulcers

K Johani, M Malone, S Jensen, I Gosbell… - International wound …, 2017 - Wiley Online Library
Increasing evidence within the literature has identified the presence of biofilms in chronic
wounds and proposed that they contribute to delayed wound healing. This research aimed …

Microbial community distribution and core microbiome in successive wound grades of individuals with diabetic foot ulcers

A Jnana, V Muthuraman, VK Varghese… - Applied and …, 2020 - Am Soc Microbiol
Diabetic foot ulcer (DFU) is a major complication of diabetes with high morbidity and
mortality rates. The pathogenesis of DFUs is governed by a complex milieu of environmental …

Interaction of the microbiome with the innate immune response in chronic wounds

EA Grice, JA Segre - Current topics in innate immunity II, 2012 - Springer
Microbes colonizing and/or infecting chronic wounds undoubtedly play a major and
interactive role in impaired healing, especially in amplifying and perpetuating the host innate …

Biofilm-innate immune interface: contribution to chronic wound formation

Z Versey, WS da Cruz Nizer, E Russell, S Zigic… - Frontiers in …, 2021 - frontiersin.org
Delayed wound healing can cause significant issues for immobile and ageing individuals as
well as those living with co-morbid conditions such as diabetes, cardiovascular disease, and …