Clinical management extra: The clinical relevance of microbiology in acute and chronic wounds

M McGuckin, R Goldman, L Bolton… - Advances in skin & …, 2003 - search.proquest.com
PURPOSE: To improve clinical practice and the quality of patient care by providing a
learning opportunity that enhances the participant's understanding of how wound …

Patient genetics is linked to chronic wound microbiome composition and healing

CD Tipton, RD Wolcott, NE Sanford, C Miller… - PLoS …, 2020 - journals.plos.org
The clinical importance of microbiomes to the chronicity of wounds is widely appreciated, yet
little is understood about patient-specific processes shaping wound microbiome …

The zone model: A conceptual model for understanding the microenvironment of chronic wound infection

K Kirketerp‐Møller, PS Stewart… - Wound Repair and …, 2020 - Wiley Online Library
In 2008, two articles in Wound Repair and Regeneration changed the clinical perspective on
chronic wounds. They stated that chronic wounds that do not heal contain bacterial biofilms …

The microbiome of diabetic foot ulcers: a comparison of swab and tissue biopsy wound sampling techniques using 16S rRNA gene sequencing

J Travis, M Malone, H Hu, A Baten, K Johani… - BMC microbiology, 2020 - Springer
Background Health-care professionals need to collect wound samples to identify potential
pathogens that contribute to wound infection. Obtaining appropriate samples from diabetic …

Time course study of delayed wound healing in a biofilm‐challenged diabetic mouse model

G Zhao, ML Usui, RA Underwood… - Wound Repair and …, 2012 - Wiley Online Library
Bacterial biofilm has been shown to play a role in delaying wound healing of chronic
wounds, a major medical problem that results in significant health care burden. A …

An in vitro model of chronic wound biofilms to test wound dressings and assess antimicrobial susceptibilities

KE Hill, S Malic, R McKee, T Rennison… - Journal of …, 2010 - academic.oup.com
Objectives The targeted disruption of biofilms in chronic wounds is an important treatment
strategy and the subject of intense research. In the present study, an in vitro model of chronic …

Biofilms in diabetic foot ulcers: significance and clinical relevance

C Pouget, C Dunyach-Remy, A Pantel, S Schuldiner… - Microorganisms, 2020 - mdpi.com
Foot infections are the main disabling complication in patients with diabetes mellitus. These
infections can lead to lower-limb amputation, increasing mortality and decreasing the quality …

Evaluation of the bacterial diversity of pressure ulcers using bTEFAP pyrosequencing

DM Smith, DE Snow, E Rees, AM Zischkau… - BMC medical …, 2010 - Springer
Background Decubitus ulcers, also known as bedsores or pressure ulcers, affect millions of
hospitalized patients each year. The microflora of chronic wounds such as ulcers most …

Use of molecular techniques to study microbial diversity in the skin: chronic wounds reevaluated

CE Davies, MJ Wilson, KE Hill… - Wound repair and …, 2001 - Wiley Online Library
The skin is colonized by an array of microorganisms which form its natural microflora.
Disruption to the normal barrier function of the skin (due to trauma or disease) may result in …

Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice

X Ding, Q Tang, Z Xu, Y Xu, H Zhang, D Zheng… - Burns & …, 2022 - academic.oup.com
Acute and chronic wound infection has become a major worldwide healthcare burden
leading to significantly high morbidity and mortality. The underlying mechanism of infections …