Post-ischemic myocardial inflammatory response: a complex and dynamic process susceptible to immunomodulatory therapies

NJ Pluijmert, DE Atsma, PHA Quax - Frontiers in Cardiovascular …, 2021 - frontiersin.org
Following acute occlusion of a coronary artery causing myocardial ischemia and
implementing first-line treatment involving rapid reperfusion, a dynamic and balanced …

The cardiac injury immune response as a target for regenerative and cellular therapies

RD Hume, JJH Chong - Clinical Therapeutics, 2020 - Elsevier
Purpose Despite modern reperfusion and pharmacologic therapies, myocardial infarction
(MI) remains a leading cause of morbidity and mortality worldwide. Therefore, the …

Bridging innate immunity and myocardial ischemia/reperfusion injury: the search for therapeutic targets

F Arslan, DPV de Kleijn, L Timmers… - Current …, 2008 - ingentaconnect.com
Myocardial infarction necessitates new therapeutic interventions, since it still results in high
morbidity and mortality worldwide. Reperfusion therapy itself results in (acceleration of) …

Immune and inflammatory networks in myocardial infarction: current research and its potential implications for the clinic

A Anzai, S Ko, K Fukuda - International journal of molecular sciences, 2022 - mdpi.com
Despite recent scientific and technological advances, myocardial infarction (MI) still
represents a major global health problem, leading to high morbidity and mortality worldwide …

The innate immune response in reperfused myocardium

L Timmers, G Pasterkamp, VC de Hoog… - Cardiovascular …, 2012 - academic.oup.com
One of the major therapeutic challenges in the arena of interventional cardiology is to design
strategies aimed at reducing myocardial tissue damage after myocardial infarction. In …

The meaning of different forms of structural myocardial injury, immune response and timing of infarct necrosis and cardiac repair

E Turillazzi, C Pomara, S Bello, M Neri… - Current Vascular …, 2015 - ingentaconnect.com
Although a decline in the all-cause and cardiac mortality rates following myocardial
infarction (MI) during the past 3 decades has been reported, MI is a major cause of death …

Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction

W Zuo, R Sun, Z Ji, G Ma - Cellular & Molecular Biology Letters, 2023 - Springer
Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …

Immune cells as targets for cardioprotection: new players and novel therapeutic opportunities

I Andreadou, HA Cabrera-Fuentes… - Cardiovascular …, 2019 - academic.oup.com
New therapies are required to reduce myocardial infarct (MI) size and prevent the onset of
heart failure in patients presenting with acute myocardial infarction (AMI), one of the leading …

The cellular immune system in the post-myocardial infarction repair process

SC Latet, VY Hoymans, PL Van Herck… - International journal of …, 2015 - Elsevier
Growing evidence indicates that overactivation and prolongation of the inflammatory
response after acute myocardial infarction (AMI) result in worse left ventricular remodelling …

[HTML][HTML] Monocytes and macrophages in cardiac injury and repair

HB Sager, T Kessler, H Schunkert - Journal of thoracic disease, 2017 - ncbi.nlm.nih.gov
Myocardial infarction (MI) is one of the major contributors to worldwide morbidity and
mortality. It is atherosclerosis' most dreadful complication and occurs after the supply of …