Lipid-polymer hybrid nanoparticles in cancer therapy: Current overview and future directions

F Persano, G Gigli, S Leporatti - Nano Express, 2021 - iopscience.iop.org
Cancer remains one of the leading cause of death worldwide. Current therapies are still
ineffective in completely eradicating the disease. In the last two decades, the use of …

Thermo-sensitive chitosan copolymer-gold hybrid nanoparticles as a nanocarrier for delivery of erlotinib

M Fathi, PS Zangabad, J Barar, A Aghanejad… - International journal of …, 2018 - Elsevier
Abstract Here, using (poly (N-isopropylacrylamide)-co-oleic acid)-g-chitosan ((PNIPAAm-co-
OA)-g-CS), CS copolymer-gold hybrid nanoparticles (CGH NPs) were synthesized by …

[HTML][HTML] Lipid polymer hybrid nanoparticles as potent vehicles for drug delivery in cancer therapeutics

S Parveen, P Gupta, S Kumar, M Banerjee - Medicine in Drug Discovery, 2023 - Elsevier
Among all diseases, cancer has the highest fatality rate in the world. Conventional therapies
have come a long way, but they still are not a panacea for cancer. Nanotechnology-based …

[HTML][HTML] Co-delivery of cisplatin and paclitaxel by folic acid conjugated amphiphilic PEG-PLGA copolymer nanoparticles for the treatment of non-small lung cancer

Z He, J Huang, Y Xu, X Zhang, Y Teng, C Huang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
An amphiphilic copolymer, folic acid (FA) modified poly (ethylene glycol)-poly (lactic-co-
glycolic acid)(FA-PEG-PLGA) was prepared and explored as a nanometer carrier for the co …

[HTML][HTML] Synergistic combination therapy of lung cancer: Cetuximab functionalized nanostructured lipid carriers for the co-delivery of paclitaxel and 5 …

S Guo, Y Zhang, Z Wu, L Zhang, D He, X Li… - Biomedicine & …, 2019 - Elsevier
Lung cancer remains the leading cause of cancer associated deaths worldwide. Recent
efforts have been focused on combinational and nanoparticulate therapies that can …

Metal (Au)-Decorated Chitosan-l-Arginine Polymeric Vector for Codelivery of Gefitinib and miR125b for Lung Cancer Therapy

C Amgoth, Y He, S Wang, K Yu, J Wang… - ACS Applied Polymer …, 2022 - ACS Publications
The progression of lung cancer is highly associated with the aberrant activation of epidermal
growth factor receptor (EGFR) tyrosine kinase and the positive feedback loop between …

Lactoferrin-appended solid lipid nanoparticles of paclitaxel for effective management of bronchogenic carcinoma

V Pandey, KR Gajbhiye, V Soni - Drug delivery, 2015 - Taylor & Francis
Lung cancer is a dreadful disease which claims to be more life threatening as compared to
total sum up of colon, prostate and breast cancers. Thus, there is an urgent need to develop …

Hyaluronic acid capped, irinotecan and gene co-loaded lipid-polymer hybrid nanocarrier-based combination therapy platform for colorectal cancer

Z Wang, A Zang, Y Wei, L An, D Hong… - Drug Design …, 2020 - Taylor & Francis
Background The current approach for treating colorectal cancer favors the use of drug and
gene combination therapy, and targeted nano-systems are gaining considerable attention …

Dual polymeric prodrug co-assembled nanoparticles with precise ratiometric co-delivery of cisplatin and metformin for lung cancer chemoimmunotherapy

T Yang, S Yu, L Liu, Y Sun, Y Lan, X Ma, R Zhu… - Biomaterials …, 2020 - pubs.rsc.org
The combination therapy of cisplatin (CDDP) and metformin (MET) is a clinical strategy to
enhance therapeutic outcomes in lung cancer. However, the efficacy of this combination is …

Combination lung cancer chemotherapy: design of a pH-sensitive transferrin-PEG-Hz-lipid conjugate for the co-delivery of docetaxel and baicalin

S Li, L Wang, N Li, Y Liu, H Su - Biomedicine & Pharmacotherapy, 2017 - Elsevier
The aim of the present study is to design a novel dual-ligand lipid based nanoparticle
system. It is conducted by a specific ligand and pH sensitive lipid conjugate. Docetaxel …