An initial proposal was made to start 30 monkeys in the run-in period of a preclinical
translational research study, to have 24 or more animals qualify for randomization in the …

In search of preclinical robustness | Nature Reviews Drug Discovery Skip to main content
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The success of preclinical research hinges on exploratory and confirmatory animal studies.
Traditional null hypothesis significance testing is a common approach to eliminate the chaff …

Abstract Objective and Background The clinical trials community has been hesitant to adopt
Bayesian statistical methods, which are often more flexible and efficient with more naturally …

I will open the first part of this paper by trying to elucidate the frequentist foundations of
RCTs. I will then present a number of methodological objections against the viability of these …

Whilst innovative Bayesian approaches are increasingly used in clinical studies, in the
preclinical area Bayesian methods appear to be rarely used in the reporting of …

Innovation is the direct intended product of certain styles in research, but not of others.
Fundamental conflicts between descriptive vs inferential statistics, deductive vs inductive …

Abstract Objective and Background We assessed current understandings in interpretation of
Bayesian and traditional statistical results within the clinical researcher (non-statistician) …

Clinical trials continue to be the gold standard for evaluating new medical technologies.
New advancements in modern computation power have led to increasing interest in …

The lack of reproducibility in biomedical research has been consistently attributed to the
misuse of statistics, naïve inference/extrapolation from animal models, and fraud. However …