Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic
mutations and loss of tumor suppressors. Mounting evidence indicates that altered …

Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to
provide energy, biosynthetic precursors and redox requirements to allow the massive …

Simple Summary Dysregulated glutamine metabolism is one of the metabolic features
evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for …

Targeting glutamine catabolism has been attracting more research attention on the
development of successful cancer therapy. Catalytic enzymes such as glutaminase (GLS) in …

Glutamine is the most abundant circulating amino acid in blood and muscle and is critical for
many fundamental cell functions in cancer cells, including synthesis of metabolites that …

Cancer cells require a robust supply of reduced nitrogen to produce nucleotides, non-
essential amino acids and a high cellular redox activity. Glutamine provides a major …

Highlights•Inhibition of glutamine metabolism is an important mechanism in cancer
control.•Novel drugs offer a mechanism by which the key metabolic enzyme glutaminase …

Targeted therapies against cancer have improved both survival and quality of life of patients.
However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic …

Many cancer cells exhibit an altered metabolic phenotype, in which glutamine consumption
is upregulated relative to healthy cells. This metabolic reprogramming often depends upon …