Abstract Objectives: Pharmacokinetic (PK)/pharmacodynamic (PD) models have become
increasingly important in optimizing antimicrobial therapy. This approach is highly …

Penetration of antiinfective drugs into soft tissues is essential for antimicrobial killing at the
target site, but is substantially lower in severely ill patients compared with healthy subjects …

Sufficient antibiotic dosing in septic patients is essential for reducing mortality. Piperacillin-
tazobactam is often used for empirical treatment, but due to the pharmacokinetic (PK) …

Antibiotic dosing in septic shock patients poses a challenge for clinicians due to the
pharmacokinetic (PK) variability seen in this patient population. Piperacillin-tazobactam is …

The objectives of this study were (i) to compare the plasma concentration–time profiles for
first-dose and steady-state piperacillin administered by intermittent or continuous dosing to …

Pharmacokinetic changes are often seen in patients with severe infections. Administration
by continuous infusion has been suggested to optimize antibiotic exposure and …

This study aimed to characterize the population pharmacokinetics (PKs) of piperacillin and
investigate probability of target attainment (PTA) and cumulative fraction of response (CFR) …

Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-
lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models …

BACKGROUND:: Investigators who perform pharmacokinetic/pharmacodynamic (PK-PD)
modeling with Monte Carlo simulation have historically not stratified microbiological data by …

Objectives: We investigated the population pharmacokinetics and pharmacodynamics of
piperacillin and tazobactam in hospitalized patients. Patients and methods: A multicentre …