Glaucoma as a neurodegenerative disease

N Gupta, YH Yücel - Current opinion in ophthalmology, 2007 - journals.lww.com
Glaucoma as a neurodegenerative disease is a valid working hypothesis to understand
neural injury in the visual system. This paradigm may stimulate the discovery of innovative …

What changes can we expect in the brain of glaucoma patients?

N Gupta, YH Yücel - Survey of ophthalmology, 2007 - Elsevier
Elevated intraocular pressure in glaucoma can injure retinal ganglion cells and trigger the
spread of disease to connected target vision structures of the brain. Glaucomatous …

A review of potential novel glaucoma therapeutic options independent of intraocular pressure

WS Shalaby, OM Ahmed, M Waisbourd, LJ Katz - Survey of Ophthalmology, 2022 - Elsevier
Glaucoma, a progressive optic neuropathy characterized by retinal ganglion cell
degeneration and visual field loss, is the leading cause of irreversible blindness worldwide …

New paradigms in the mechanisms and management of glaucoma

HA Quigley - Eye, 2005 - nature.com
During the last 30 years, the definition of glaucoma as been revised to eliminate the
inclusion of intraocular pressure. Open angle glaucoma is the second leading cause of …

Links among glaucoma, neurodegenerative, and vascular diseases of the central nervous system

C Nucci, A Martucci, M Cesareo, F Garaci… - Progress in brain …, 2015 - Elsevier
Glaucoma is the leading cause of irreversible blindness worldwide. Although the intraocular
pressure (IOP) has been considered for long time the key point and the only treatable risk …

Is neuroprotection a viable therapy for glaucoma?

RN Weinreb, LA Levin - Archives of ophthalmology, 1999 - jamanetwork.com
Treatment of glaucoma continues to be directed at lowering intraocular pressure to decrease
the likelihood of disease progression. In the future intraocular pressure reduction might be …

[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering

JR Tribble, F Hui, H Quintero, S El Hajji, K Bell… - Molecular aspects of …, 2023 - Elsevier
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

Neuroprotection in glaucoma

SK Vasudevan, V Gupta… - Indian journal of …, 2011 - journals.lww.com
Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells
and their axons. Recent evidence suggests that intraocular pressure (IOP) is only one of the …

[HTML][HTML] What is glaucoma?

D Križaj - Webvision: The Organization of the Retina and Visual …, 2019 - ncbi.nlm.nih.gov
Glaucoma, a leading cause of blindness in the world, can be challenging to diagnose
because symptoms often appear at late stage of the disease, and challenging to treat …

[HTML][HTML] Focus: the aging brain: neurodegeneration and neuroprotection in glaucoma

AC Gauthier, J Liu - The Yale journal of biology and medicine, 2016 - ncbi.nlm.nih.gov
Glaucoma is the principal cause of irreversible blindness in the world. The disease leads to
progressive optic nerve degeneration with a gradual loss of retinal ganglion cells …