Thyroid hormones control growth, development, differentiation and metabolism in
vertebrates. Most of the actions of the active thyroid hormone T3 (3, 5, 3′-triiodo-l …

The human thyroid gland secretes thyroid hormones under the control of the hypothalamus-
pituitary-periphery feedback axis already during the last fetal trimester and is the only …

The goal of this review is to place the exciting advances that have occurred in our
understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3 …

Thyroid hormone signaling is customized in a time and cell-specific manner by the
deiodinases, homodimeric thioredoxin fold containing selenoproteins. This ensures …

The type III iodothyronine deiodinase metabolizes the active thyroid hormones thyroxine and
3, 5, 3'-triiodothyronine to inactive compounds. Recently, we have characterized a Xenopus …

The thyroid hormone plays a fundamental role in the development, growth, and metabolic
homeostasis in all vertebrates by affecting the expression of different sets of genes. A group …

The deiodination of thyroid hormones in extrathyroidal tissues plays an important role in
modulating thyroid hormone action. The type II deiodinase (DII) converts thyroxine to the …

Tissue-specific activation and inactivation of ligands of nuclear receptors which belong to
the steroid–retinoid–thyroid hormone superfamily of trancsription factors represents an …

Development and tissue-specific deiodination of thyroid hormone leads to both activation of
the prohormone thyroxine to the thyromimetically active T3 as well as to inactivation of T3 …

Thyroxine (T4) is a prohormone and must be activated to 3, 5, 3′-triiodothyronine (T3) by
either type 1 (D1) or type 2 (D2) selenodeiodinase. A third deiodinase (D3) inactivates T3 or …