Wilms tumor is an embryonic renal cancer that typically presents in early childhood and
accounts for 7% of all paediatric cancers. Different genetic alterations have been described …

Simple Summary About 7% of all children's malignancies are represented by the embryonal
renal cancer Wilms tumor (WT). Since methylation imprinting alterations at multiple loci …

Wilms' tumor (WT) is the most frequent renal cancer in childhood, the occurrence of which is
characterized by a relatively low frequency of associated mutations. While epigenetic …

Background Although cure rates for Wilms tumours (WT) are high, many patients receive
therapy with attendant long-term complications. Our goal was to stratify WT using genome …

Wilms tumour is the most common renal malignancy of childhood. The disease is curable in
the majority of cases, albeit at considerable cost in terms of late treatment-related effects in …

Wilms' tumor of the kidney (WT) is the most common solid tumor of childhood, and it was first
described in detail by Max Wilms' in 1899. WT is a paradigm of childhood cancer, because it …

Epigenetic abnormalities at the IGF2/H19 locus play a key role in the onset of Wilms tumor.
These tumors can be classified into three molecular subtypes depending on the events …

Background Wilms tumor (WT) is a curable pediatric renal malignancy, but there is a need
for new molecular biomarkers to improve relapse risk-directed therapy. Somatic alterations …

Abstract Background Wilms tumours (WTs) are characterised by several hallmarks that
suggest epimutations such as aberrant DNA methylation are involved in tumour progression …

Developing synchronous bilateral Wilms tumor suggests an underlying (epi) genetic
predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or …