Abstract Connexin46 (Cx46), together with Cx50, forms gap junction channels between lens
fibers and participates in the lens pump-leak system, which is essential for the homeostasis …

Connexin channels play a critical role in maintaining metabolic homeostasis and
transparency of the lens. Mutations in connexin genes are linked to congenital cataracts in …

Human connexin46 (hCx46) forms gap junctional channels interconnecting lens fiber cells
and appears to be critical for normal lens function, because hCx46 mutations have been …

Abstract Connexin 46 (Cx46) is important for gap junction channels formation which plays
crucial role in the preservation of lens homeostasis and transparency. Previously, we have …

The human lens is an avascular organ, and its transparency is dependent on gap junction
(GJ)-mediated microcirculation. Lens GJs are composed of three connexins with Cx46 and …

The mutation N188T in human connexin46 (hCx46) correlates with a congenital nuclear
pulverulent cataract. This mutation is in the second extracellular loop, a domain involved in …

Purpose.: To determine the consequences of expression of a novel connexin50 (CX50)
mutant identified in a child with congenital total cataracts. Methods.: The GJA8 gene was …

Mutations in Connexin50 (Cx50) cause cataracts in both humans and mice. The mechanism
(s) behind how mutated connexins lead to a variety of cataracts have yet to be fully …

Gap junction channels, which are made of connexins, are critical for intercellular
communication, a function that may be disrupted in a variety of diseases. We studied the …

Mutations within connexin50 (Cx50) have been linked to various cataract phenotypes. To
determine the mechanism behind cataract formation we used the paired Xenopus oocyte …