During the last decades, the incidence of type 1 diabetes (T1D) has increased significantly,
reaching percentages of 3% annually worldwide. This increase suggests that besides …

The most popular hypothesis circulating within and beyond the scientific community is that
viral infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed …

In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8+ T
cells, together with a significant number of other inflammatory cells, including CD8+ T …

Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by the loss of
pancreatic beta cells in the islets of Langerhans. Although genetic predisposition plays an …

The precise etiology of type 1 diabetes (T1D) is still unknown, but viruses have long been
suggested as a potential environmental trigger for the disease. However, despite decades of …

Abstract Type 1 diabetes (T1D) is the most common chronic metabolic disorder in children.
Epigenetic and environmental factors capable of altering the penetrance of major …

More than 10 viruses have been reported to be associated with the development of type 1
diabetes‐like symptoms in animals, with the best evidence coming from studies on the D …

We will take a journey from basic pathogenetic mechanisms elicited by viral infections that
play a role in the development of type 1 diabetes to clinical interventions, where we will …

Insulin‐dependent diabetes mellitus (IDDM) is a multifactorial disease. Besides a genetic
predisposition environmental factors have been implicated in the pathogenesis of β cell …

Type 1 diabetes results from the destruction of pancreatic beta cells. Genetic factors are
believed to be a major component for the development of type 1diabetes, but the …