Background Alternative splicing isoforms have been reported as a new and robust class of
diagnostic biomarkers. Over 95% of human genes are estimated to be alternatively spliced …

Background In the biopharmaceutical industry, biomarkers define molecular taxonomies of
patients and diseases and serve as surrogate endpoints in early-phase drug trials …

Breast cancer is the most common cause of cancer death among women under age 50
years, so it is imperative to identify molecular markers to improve diagnosis and prognosis of …

Background Clinical proteomics application aims at solving a specific clinical problem within
the context of a clinical study. It has been growing rapidly in the field of biomarker discovery …

Background Alternative splicing provides a major mechanism to generate protein diversity.
Increasing evidence suggests a link of dysregulation of splicing associated with cancer …

Alternative splicing is pivotal to the regulation of gene expression and protein diversity in
eukaryotic cells. The detection of alternative splicing events requires specific omics …

Alternative splicing plays an important role in protein diversity without increasing genome
size. Earlier thought to be uncommon, splicing appears to affect the majority of genes …

[Frontiers in Bioscience 12, 4034-4041, May 1, 2007] 4034 Genomic analysis of RNA
alternative splicing in cancers Yi Xing Depar Page 1 [Frontiers in Bioscience 12, 4034-4041 …

Alternative splicing of mRNA precursors allows the synthesis of multiple mRNAs from a
single primary transcript, thus contributing to proteomic diversity in higher eukaryotes …

Background Alternative splicing is an important and widespread mechanism for generating
protein diversity and regulating protein expression. High-throughput identification and …