Elevated levels of Chitinase-3-like protein-1 (CHI3L1) in cerebrospinal fluid have previously
been linked to inflammatory activity and disease progression in multiple sclerosis (MS) …

Background and purpose This study was undertaken to determine the diagnostic and
prognostic value of a panel of serum biomarkers and to correlate their concentrations with …

Amyotrophic lateral sclerosis is a rapidly progressive neurodegenerative disease that affects
upper (UMN) and lower motor (LMN) neurons. It is associated with a short survival and there …

Abstract Previously, chitinase 3-like 1 (CHI3L1) protein level was increased in various
inflammatory conditions and cancers. This study was aimed to evaluate the plasma CHI3L1 …

Amyotrophic lateral sclerosis (ALS) is the most prevalent form of adult-onset motor neuron
disease with a median survival of 2–3 years from symptom onset. No cure exists as …

There is a need for biomarkers for amyotrophic lateral sclerosis (ALS), to support the
diagnosis of the disease, to predict disease progression and to track disease activity and …

Abstract Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease, still
incurable. The disease is highly heterogenous both genetically and phenotypically …

J. Neurochem.(2011) 117, 528–537. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly
progressive and ultimately fatal neurodegenerative disease with an average survival of 3 …

Abstract Chitinase 3-like 1 (CHI3L1) is known to play a role as prognostic biomarker in the
early stages of multiple sclerosis (MS), and patients with high cerebrospinal fluid CHI3L1 …

Background: Neurofilament light chain protein (NFL) and chitinase3-like1 (CHI3L1) have
gained importance recently as prognostic biomarkers in multiple sclerosis (MS). Objectives …