Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder of motor
neurons leading to death of the patients, mostly within 2–5 years after disease onset. The …

Background and purpose The prognostic value of serum neurofilament light chain (sNfL), a
biomarker of neurodegeneration, compared to other prognostic factors of amyotrophic lateral …

The lack of biomarkers for early diagnosis, clinical stratification and to monitor treatment
response has hampered the development of new therapies for amyotrophic lateral sclerosis …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease among
adults. With diagnosis reached relatively late into the disease process, extensive motor cell …

Insights into the mechanisms of amyotrophic lateral sclerosis (ALS) have relied
predominantly on the study of postmortem tissue. Modern technology has improved the …

Objective Phosphorylated neurofilament heavy chain (pNfH) levels are elevated in
cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). Instead of …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a
progressive upper and lower motor neuron degeneration. One of the peculiar clinical …

Motor neuron disease (MND) is a rare group of disorders characterized by degeneration of
motor neurons (MNs). The most common form of MND, amyotrophic lateral sclerosis (ALS) …

Neurofilament levels are elevated in many neurodegenerative diseases and have shown
promise as diagnostic and prognostic biomarkers in Amyotrophic Lateral Sclerosis (ALS) …

Motor neuron disease includes a heterogeneous group of relentless progressive
neurological disorders defined and characterized by the degeneration of motor neurons …