Myoglobin is an important intracellular O2 binding hemoprotein in heart and skeletal muscle.
Surprisingly, disruption of myoglobin in mice (myo−/−) resulted in no obvious phenotype and …

Continuous contractile activity of the heart is essential and the required energy is mostly
provided by fatty acid (FA) oxidation. Myocardial lipid accumulation can lead to pathological …

Myoglobin (Mb) is a regulator of O2 bioavailability in type I muscle and heart, at least when
tissue O2 levels drop. Mb also plays a role in regulating cellular nitric oxide (NO) pools …

Recent studies of myoglobin (Mb) knockout (myo−/−) mice have extended our
understanding of Mb's diverse functions and have demonstrated a complex array of …

Myoglobin may serve a variety of functions in muscular oxygen supply, such as O2 storage,
facilitated O2 diffusion, and myoglobin-mediated oxidative phosphorylation. We studied the …

Myoglobin (Mb) regulates O2 bioavailability in muscle and heart as the partial pressure of
O2 (Po2) drops with increased tissue workload. Globin proteins also modulate cellular NO …

Myoglobin is a cytoplasmic hemoprotein that is restricted to cardiomyocytes and oxidative
skeletal muscle fibers. Myoglobin is a well-characterized protein and numerous studies have …

In this study, the hemodynamic effects of acute myoglobin (Mb) inhibition with CO on
isolated hearts of wild‐type (WT) mice were examined at different degrees of oxygenation …

A canonical view of the primary physiological function of myoglobin (Mb) is that it is an
oxygen (O2) storage protein supporting mitochondrial oxidative phosphorylation, especially …

Myoglobin (Mb) is an intensely studied hemoprotein that is restricted mainly to the heart and
oxidative myofibers in skeletal muscle. Previous physiologic and pharmacologic studies …