Cofilin is a member of the actin-depolymerizing factor (ADF) family protein, which plays an
essential role in regulation of the mitochondrial apoptosis. It remains unclear how cofilin …

Background Arnidiol is a pentacyclic triterpene diol that has multiple pharmacological
activities. However, the apoptotic activities of arnidiol in human cancer cells have not yet …

Mitochondria fission and mitophagy are fundamentally crucial to cellular physiology and
play important roles in cancer progression. Developing a comprehensive understanding of …

Mitochondria form highly dynamic networks in which organelles constantly fuse and divide.
The relevance of mitochondrial dynamics is evident from its implication in various human …

In this study, we determined that cerulenin, a natural product inhibitor of fatty acid synthase,
induces mitochondrial injury and apoptosis in human leukemia cells through the …

Background Cofilin is a member of the actin depolymerizing factor (ADF)/cofilin family, which
regulates actin dynamics. Increasing evidence suggests that mitochondrial translocation of …

Withaferin A (WA), a steroidal lactone derived from a medicinal plant (Withania somnifera),
inhibits cancer development in transgenic and chemically-induced rodent models of breast …

Increasing evidence suggests that movement of key proteins in or out of mitochondria during
apoptosis is essential for the regulation of apoptosis. Here, we report identification of the …

Treatments targeting oncogenic fusion proteins are notable examples of successful drug
development. Abnormal splicing of genes resulting in fusion proteins is a critical driver of …

IR‐783 is a kind of heptamethine cyanine dye that exhibits imaging, cancer targeting and
anticancer properties. A previous study reported that its imaging and targeting properties …