Metabolic Function of Corynebacterium glutamicum Aminotransferases AlaT and AvtA and Impact on l-Valine Production

J Marienhagen, L Eggeling - Applied and environmental …, 2008 - Am Soc Microbiol
Aminotransferases (ATs) interacting with l-alanine are the least studied bacterial ATs.
Whereas AlaT converts pyruvate to l-alanine in a glutamate-dependent reaction, AvtA is able …

Influence of l-isoleucine and pantothenate auxotrophy for l-valine formation in Corynebacterium glutamicum revisited by metabolome analyses

T Bartek, P Makus, B Klein, S Lang… - Bioprocess and biosystems …, 2008 - Springer
The effect of different amounts of supplemented l-isoleucine and pantothenate has been
analysed with the auxotrophic strain Corynebacterium glutamicum ΔilvA ΔpanB, showing …

Linking Central Metabolism with Increased Pathway Flux: l-Valine Accumulation by Corynebacterium glutamicum

E Radmacher, A Vaitsikova, U Burger… - Applied and …, 2002 - Am Soc Microbiol
Mutants of Corynebacterium glutamicum were made and enzymatically characterized to
clone ilvD and ilvE, which encode dihydroxy acid dehydratase and transaminase B …

Global Expression Profiling and Physiological Characterization of Corynebacterium glutamicum Grown in the Presence of l-Valine

C Lange, D Rittmann, VF Wendisch… - Applied and …, 2003 - Am Soc Microbiol
Addition of l-valine (50 to 200 mM) to glucose minimal medium had no effect on the growth
of wild-type Corynebacterium glutamicum ATCC 13032 but inhibited the growth of the …

Functional Analysis of All Aminotransferase Proteins Inferred from the Genome Sequence of Corynebacterium glutamicum

J Marienhagen, N Kennerknecht, H Sahm… - Journal of …, 2005 - Am Soc Microbiol
Twenty putative aminotransferase (AT) proteins of Corynebacterium glutamicum, or rather
pyridoxal-5′-phosphate (PLP)-dependent enzymes, were isolated and assayed among …

Metabolic design in amino acid producing bacterium Corynebacterium glutamicum

H Sahm, L Eggeling, B Eikmanns… - FEMS Microbiology …, 1995 - academic.oup.com
Abstract The Gram-positive bacterium Corynebacterium glutamicum is used for the industrial
production of amino acids, eg of l-glutamate and l-lysine. In the last 10 years, genetic …

Metabolic Engineering of Corynebacterium glutamicum for l-Serine Production

P Peters-Wendisch, M Stolz, H Etterich… - Applied and …, 2005 - Am Soc Microbiol
Although l-serine proceeds in just three steps from the glycolytic intermediate 3-
phosphoglycerate, and as much as 8% of the carbon assimilated from glucose is directed …

L-valine production in Corynebacterium glutamicum based on systematic metabolic engineering: progress and prospects

J Liu, JZ Xu, B Wang, ZM Rao, WG Zhang - Amino Acids, 2021 - Springer
L-valine is an essential branched-chain amino acid that cannot be synthesized by the
human body and has a wide range of applications in food, medicine and feed. Market …

Genome-based analysis of biosynthetic aminotransferase genes of Corynebacterium glutamicum

AC McHardy, A Tauch, C Rückert, A Pühler… - Journal of …, 2003 - Elsevier
Due to broad and overlapping substrate specificities, aminotransferases remain the last
uncharacterized enzymes from most amino acid biosynthetic pathways in Corynebacterium …

Efficient fermentative production of l-theanine by Corynebacterium glutamicum

H Ma, X Fan, N Cai, D Zhang, G Zhao, T Wang… - Applied microbiology …, 2020 - Springer
Abstract l-Theanine is a unique non-protein amino acid found in tea plants that has been
shown to possess numerous functional properties relevant to food science and human …