Regulations encouraging pediatric investigation of new drugs are advancing the therapeutic
pharmacopoeia, but for many commonly used medicines, the lack of well-conducted …

Regulations encouraging pediatric investigation of new drugs are advancing the therapeutic
pharmacopoeia, but for many commonly used medicines the lack of well-conducted …

Pharmacokinetic pharmacodynamic modeling is an important tool which uses statistical
methodology to provide a better understanding of the relationship between concentration …

Clinical implications of pharmacokinetics and pharmacodynami... : Current Opinion in Pediatrics
Clinical implications of pharmacokinetics and pharmacodynamics of procedural sedation agents …

Background: Physiological‐based pharmacokinetic models have been used to describe
midazolam clearance (CL) maturation. There are no maturation descriptors of CL from …

Abstract The pharmacokinetics (PK), pharmacodynamics (PD) and side effect profile of most
medications used in children differ from those in adults; these differences are most …

Pain, anxiety, fear, distress, and agitation are often experienced by children undergoing
medical treatment. Contributory factors may include separation from parents, unfamiliar …

The pharmacokinetic (PK) parameters that are important for dosing (eg, clearance and
volume) are well known. They are used in universal mathematical formulae that describe the …

Clinical pharmacology aims to quantify drug-specific (side)-effects based on
pharmacokinetics (PK) and pharmacodynamics (PD). PK (absorption, distribution …

Mechanistic models create a framework for the study of pharmacokinetic changes in infancy.
Understanding these changes allows a target concentration approach to therapy and …