It is important to distinguish age-related differences in pharmacology for infants and young
children compared with older children and adults. In the first year of life, pharmacokinetic …

The Interplay between Pharmacokinetics and Pharmacodynamics | Pediatrics In Review |
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Objective The aim of this study was to evaluate the pharmacodynamics and safety of
midazolam after intravenous infusion or oral administration in preterm infants. Methods] …

A larger number of studies are being conducted in paediatric patients for drug development
than has ever occurred previously as a result of the current legislative acts in the US and …

Medical research in children typically lags behind that of adult research in both quantity and
quality. The conduct of rigorous clinical trials in children can raise ethical concerns because …

Safe and efficacious drug therapy in neonates, infants and children require detailed
knowledge about the ontogeny of drug disposition and action as well how these interact with …

Selection of the first dose for neonates in clinical trials is very challenging. The objective of
this analysis was to assess if a population pharmacokinetic (PK) model developed with data …

This commentary reflects current developments in pediatric medicine. The underpinning
legislation in both Europe and the United States has led to the initiation of an increased …

Background: Effective and safe pharmacotherapy in an individual neonate necessitates
understanding the pharmacokinetic (PK) and pharmacodynamic (PD) properties of a specific …