Introduction: The target concentration strategy uses PKPD information for dose
determination. Models have also quantified exposure-response relationships, improved …

Paediatric patients, particularly preterm neonates, present many pharmacological
challenges. Due to the difficulty in conducting clinical trials in these populations dosing …

Effective pain management remains an important indicator of the quality of care provided to
neonates, not only from an ethical, but also from a clinical outcome perspective. Significant …

Core clinical pharmacology principles must be considered when designing and executing
neonatal clinical trials. In this review, the authors discuss important aspects of drug dose …

Objective This review addresses sedation management on paediatric intensive care units
and possible gaps in the knowledge of optimal sedation strategies. We present an overview …

Historically, many commercially available drugs were not investigated sufficiently and/or
authorized for pediatric use (children age from 0 to 16 years)[1]. Consequently, physicians …

Reluctance to enroll pediatric subjects in clinical trials has left gaps in information about
dosing, safety, and efficacy of medications. Pharmacotherapeutic information for pediatric …

Children are not small adults because besides size there are subtle physiological and
biochemical differences between children and adults. Like adults, children also require …

Rational drug use in special populations is a clinical problem that doctors and pharma-cists
must consider seriously. Neonates are the most physiologically immature and vulnerable to …