Sex differences in the phosphoproteomic profiles of APP/PS1 mice after chronic unpredictable mild stress

S Dominguez, G Rodriguez, H Fazelinia… - Journal of …, 2020 - content.iospress.com
Approximately two-thirds of those suffering with Alzheimer's disease (AD) are women,
however, the biological mechanisms underlying this sex divergence of AD prevalence …

Central CRF system perturbation in an Alzheimer's disease knockin mouse model

Q Guo, H Zheng, NJ Justice - Neurobiology of aging, 2012 - Elsevier
Alzheimer's disease (AD) is often accompanied by changes in mood as well as increases in
circulating cortisol levels, suggesting that regulation of the stress responsive hypothalamic …

[HTML][HTML] Sex differences in chronic stress responses and Alzheimer's disease

Y Yan, S Dominguez, DW Fisher, H Dong - Neurobiology of stress, 2018 - Elsevier
Clinical studies indicate that Alzheimer's disease (AD) disproportionately affects women in
both disease prevalence and severity, but the mechanisms underlying this sex divergence …

Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice

CE Lyons, X Zhou, M Razzoli, M Chen… - European Journal of …, 2022 - Wiley Online Library
Late onset, sporadic Alzheimer's disease (AD) accounts for the vast majority of cases. Unlike
familial AD, the factors that drive the onset of sporadic AD are poorly understood, although …

Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer's disease-related signaling

DA Bangasser, H Dong, J Carroll, Z Plona, H Ding… - Molecular …, 2017 - nature.com
Several neuropsychiatric and neurodegenerative disorders share stress as a risk factor and
are more prevalent in women than in men. Corticotropin-releasing factor (CRF) orchestrates …

Loss of glucocorticoid receptor phosphorylation contributes to cognitive and neurocentric damages of the amyloid-β pathway

Y Dromard, M Arango-Lievano, A Borie… - Acta Neuropathologica …, 2022 - Springer
Aberrant cortisol and activation of the glucocorticoid receptor (GR) play an essential role in
age-related progression of Alzheimer's disease (AD). However, the GR pathways required …

Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice

SL Lesuis, S Weggen, S Baches, PJ Lucassen… - Translational …, 2018 - nature.com
Exposure to chronic stress or elevated glucocorticoid hormone levels in adult life has been
associated with cognitive deficits and an increased risk for Alzheimer's disease (AD). Since …

Acute stressors do not impair short-term memory or attention in an aged mouse model of amyloidosis

GM DiMarco, BN Harris, AV Savonenko… - Frontiers in Behavioral …, 2023 - frontiersin.org
Memory impairment in Alzheimer's disease patients is thought to be associated with the
accumulation of amyloid-beta peptides and tau proteins. However, inconsistent reports of …

Sex-dependent effects of acute stress on amyloid-β in male and female mice

HM Edwards, CE Wallace, WD Gardiner, BM Doherty… - Brain, 2023 - academic.oup.com
The risk of developing Alzheimer's disease is mediated by a combination of genetics and
environmental factors, such as stress, sleep abnormalities and traumatic brain injury …

Endocrine stress responsivity and social memory in 3xTg-AD female and male mice: A tale of two experiments

ET Nguyen, D Selmanovic, M Maltry, R Morano… - Hormones and …, 2020 - Elsevier
Stress confers risk for the development and progression of Alzheimer's disease (AD).
Relative to men, women are disproportionately more likely to be diagnosed with this …