Impact of host immunity on HTLV-1 pathogenesis: potential of Tax-targeted immunotherapy against ATL

M Kannagi, A Hasegawa, Y Nagano, S Kimpara… - Retrovirology, 2019 - Springer
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL),
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and other …

A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells

S Millen, L Meretuk, T Göttlicher, S Schmitt… - Retrovirology, 2020 - Springer
Background Human T-cell leukemia virus type 1 (HTLV-1) infects primarily CD4+ T-
lymphocytes and evoques severe diseases, predominantly Adult T-Cell …

The roles of acquired and innate immunity in human T-cell leukemia virus type 1-mediated diseases

M Kannagi, A Hasegawa, A Takamori… - Frontiers in …, 2012 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and HTLV-
1-associated myelopathy/tropical spastic paraparesis in small subsets of HTLV-1 carriers …

[HTML][HTML] HTLV deregulation of the NF-κB pathway: An update on tax and antisense proteins role

S Fochi, S Mutascio, U Bertazzoni, D Zipeto… - Frontiers in …, 2018 - frontiersin.org
Human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell
leukemia (ATL), an aggressive CD4+/CD25+ T-cell malignancy and of a severe …

HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

R Currer, R Van Duyne, E Jaworski, I Guendel… - Frontiers in …, 2012 - frontiersin.org
Human T-cell lymphotropic virus type 1 (HTLV-1) has been identified as the causative agent
of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic …

Mechanisms of oncogenesis by HTLV-1 Tax

S Mohanty, EW Harhaj - Pathogens, 2020 - mdpi.com
The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell
leukemia/lymphoma (ATLL), a neoplasm of CD4+ CD25+ T cells that occurs in 2–5% of …

[HTML][HTML] HTLV-1 HBZ viral protein: a key player in HTLV-1 mediated diseases

M Baratella, G Forlani, RS Accolla - Frontiers in microbiology, 2017 - frontiersin.org
Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic human retrovirus that has
infected 10–15 million people worldwide. After a long latency, 3–5% of infected individuals …

HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells

N Araya, T Sato, H Ando, U Tomaru… - The Journal of …, 2014 - Am Soc Clin Investig
Human T-lymphotropic virus type 1 (HTLV-1) is linked to multiple diseases, including the
neuroinflammatory disease HTLV-1–associated myelopathy/tropical spastic paraparesis …

Oncogenic human T-cell lymphotropic virus type 1 tax suppression of primary innate immune signaling pathways

J Hyun, JC Ramos, N Toomey, S Balachandran… - Journal of …, 2015 - Am Soc Microbiol
Human T-cell lymphotropic virus type I (HTLV-1) is an oncogenic retrovirus considered to be
the etiological agent of adult T-cell leukemia (ATL). The viral transactivator Tax is regarded …

Modulation of nuclear factor-ϰB by human T cell leukemia virus type 1 tax protein: Implications for oncogenesis and inflammation

JM Peloponese, ML Yeung, KT Jeang - Immunologic research, 2006 - Springer
Activation of the nuclear factor kappa B (NF-ϰB) transcription factor family by different
stimuli, such as inflammatory cytokines, stress inducers, or pathogens, results in innate and …