[HTML][HTML] Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes
C Davegårdh, E Hall Wedin, C Broholm… - Stem Cell Research & …, 2019 - Springer
Background Sex differences are known to impact muscle phenotypes, metabolism, and
disease risk. Skeletal muscle stem cells (satellite cells) are important for muscle repair and …
disease risk. Skeletal muscle stem cells (satellite cells) are important for muscle repair and …
[HTML][HTML] DNA methylation patterning and the regulation of beta cell homeostasis
N Parveen, S Dhawan - Frontiers in Endocrinology, 2021 - frontiersin.org
Pancreatic beta cells play a central role in regulating glucose homeostasis by secreting the
hormone insulin. Failure of beta cells due to reduced function and mass and the resulting …
hormone insulin. Failure of beta cells due to reduced function and mass and the resulting …
[HTML][HTML] Characterization of tissue-specific differential DNA methylation suggests distinct modes of positive and negative gene expression regulation
Background DNA methylation plays an important role in regulating gene expression during
many biological processes. However, the mechanism of DNA-methylation-dependent gene …
many biological processes. However, the mechanism of DNA-methylation-dependent gene …
[HTML][HTML] Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells
Background DNA methylation patterns are initiated by de novo DNA methyltransferases
DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated genome of …
DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated genome of …
DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) in mouse promoter regions demonstrating tissue-specific gene expression
S Yagi, K Hirabayashi, S Sato, W Li… - Genome …, 2008 - genome.cshlp.org
DNA methylation constitutes an important epigenetic regulation mechanism in many
eukaryotes, although the extent of DNA methylation in the regulation of gene expression in …
eukaryotes, although the extent of DNA methylation in the regulation of gene expression in …
[HTML][HTML] DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism
Osteoarthritis (OA) is the most common form of arthritis worldwide. It is a complex disease
affecting the whole joint but is generally characterized by progressive degradation of …
affecting the whole joint but is generally characterized by progressive degradation of …
[HTML][HTML] Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes
RF Pérez, P Santamarina, JR Tejedor… - Journal of translational …, 2019 - Springer
Background Early life is a period of drastic epigenetic remodeling in which the epigenome is
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …
[HTML][HTML] A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue
Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …
diseases. The epigenome differs between cell types and has until now only been …
An epigenetic clock for human skeletal muscle
Background Ageing is associated with DNA methylation changes in all human tissues, and
epigenetic markers can estimate chronological age based on DNA methylation patterns …
epigenetic markers can estimate chronological age based on DNA methylation patterns …
Genome-wide quantification of the effects of DNA methylation on human gene regulation
Changes in DNA methylation are involved in development, disease, and the response to
environmental conditions. However, not all regulatory elements are functionally methylation …
environmental conditions. However, not all regulatory elements are functionally methylation …