DNA methyltransferases (DNMTs) play an essential role in DNA methylation and
transcriptional regulation in the genome. DNMTs, along with other poorly studied elements …

Exercise and physical activity induces physiological responses in organisms, and
adaptations in skeletal muscle, which is beneficial for maintaining health and preventing …

DNA methylation is an important epigenetic modification that can regulate gene expression
following environmental encounters without changes to the genetic code. Using Infinium …

Mouse embryos acquire global DNA methylation of their genome during implantation.
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …

DNA methylation is an epigenetic modification that plays a crucial role in normal mammalian
development, retrotransposon silencing, and cellular reprogramming. Although methylation …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

The somatic DNA methylation (DNAme) landscape is established early in development but
remains highly dynamic within focal regions that overlap with gene regulatory elements. The …

Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …

Aims/hypothesis The association between low birthweight (LBW) and risk of developing type
2 diabetes may involve epigenetic mechanisms, with skeletal muscle being a prime target …

DNA methylation is a defining feature of mammalian cellular identity and is essential for
normal development,. Most cell types, except germ cells and pre-implantation embryos …